2-Propenenitrile, reaction products with 3-amino-1,5,5-trimethylcyclohexanemethanamine

Endpoint summary

Description of key information

The physicochemical and biological data on the test substance suggests that it is readily bioavailable. The test substance would be distributed systemically in the water phase, but would not tend to partition into lipid tissues, it appears to be metabolised and eliminated relatively rapidly.

Key value for chemical safety assessment

Bioaccumulation potential:

low bioaccumulation potential

Additional information

A toxicokinetic assessment was conducted based on available physico-chemical properties and toxicological data of the test substance. Data from dermal irritation and skin sensitization indicates relatively good skin penetration even at low concentrations. Examination of the data from the repeat dose oral studies gave an indication of there being good evidence for oral bioavailability by the oral route for the test substance. The high water solubility and low Log Kow suggests relatively high rates of intestinal bioavailability. The biological effects (at dose levels above 300 mg/kg bw/day) following administration of an aqueous solution of test substance confirms the bioavailability. The relatively low volatility suggests a low risk of inhalation exposure. The low vapour pressure suggests low concentrations in air at room temperature which would not be expected to be of any concern. The studies performed and the available physico-chemical data are consistent with an organic molecule with a high bioavailability with no indication or evidence for potential for bioaccumulation. The low Log Kow, the high water solubility and the mammalian toxicity after oral doses at high levels supports the concept of high bioavailability. Low melting point and surface activity would also facilitate high bioavailability. A lack of cumulative toxicity for a chemical with known toxicity supports the concept of rapid elimination of the chemicals. Again, the high water solubility and low Log Kow suggest equilibrium with the water phase in animals, and would not tend to partition onto lipid tissues. The high water solubility would allow rapid excretion in urine. The low toxicity to fish and Daphnia, and the very high water solubility (allowing rapid dilution in the environment) suggest there is not a high risk in environmental exposure scenarios. Based on the above information, the physico-chemical and biological data on the test substance suggests that it is readily bioavailable. The test substance would be distributed systemically in the water phase, but would not tend to partition into lipid tissues, it appears to be metabolised and eliminated relatively rapidly (Esdaile DJ, 2015).