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EC number: 226-558-7 | CAS number: 5424-01-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 February 2013 - 28 March 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed in accordance with the EC A.6 and OECD 105 guidelines and complied with the principles of GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (1995)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- (1998)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- 3-aminopyrazine-2-carboxylic acid
- EC Number:
- 226-558-7
- EC Name:
- 3-aminopyrazine-2-carboxylic acid
- Cas Number:
- 5424-01-1
- Molecular formula:
- C5H5N3O2
- IUPAC Name:
- 3-aminopyrazine-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Amiloride Compound 5
- Description: Tan powder
- Storage condition of test material: In refrigerator (2-8°C) protected from light, desiccated
- Other: Reactive to light, moisture and oxygen
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 2.4 g/L
- Temp.:
- 20 °C
- pH:
- 2.8
- Remarks on result:
- other: Mean of the analysed concentrations at t 24, 48 and 72 h.
Any other information on results incl. tables
Water solubility results
Stirring time
[hours] |
Analysed concentration [g/l] |
Mean
[g/l] |
MD
[%] |
pH
|
|
|
|
|
|
24 |
2.37 |
2.40 |
3.5 |
2.8 |
48 |
2.39 |
|
|
2.8 |
72 |
2.45 |
|
|
2.8 |
A small response at the retention time of the test substance was detected in the chromatogram of the pretreated sample from the blank water mixture. The maximum contribution to the samples taken at 24, 48 and 72 hours was 2.1% based on peak area.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of Amiloride Compound 5 at 20°C was determined to be 2.4 g/L using the flask method (GLP-compliant study in accordance with EC A.6, OECD 105 and OPPTS 830.7840). The pH was 2.8.
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