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EC number: 419-210-2 | CAS number: 178452-71-6 OLIVE-GREEN JB 1170
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- Adopted July 17, 1992 (reported Paris April 29, 1993).
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- July 31, 1992.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Pentasodium bis{7-[4-(1-butyl-5-cyano-1,2-dihydro-2-hydroxy-4-methyl-6-oxo-3-pyridylazo)phenylsulfonylamino]-5'-nitro-3,3'-disulfonatonaphthalene-2-azobenzene-1,2'-diolato} chromate (III)
- EC Number:
- 419-210-2
- EC Name:
- Pentasodium bis{7-[4-(1-butyl-5-cyano-1,2-dihydro-2-hydroxy-4-methyl-6-oxo-3-pyridylazo)phenylsulfonylamino]-5'-nitro-3,3'-disulfonatonaphthalene-2-azobenzene-1,2'-diolato} chromate (III)
- Cas Number:
- 178452-71-6
- Molecular formula:
- C66H48CrN16Na5O28S6
- IUPAC Name:
- chromium(3+) pentasodium bis(7-{4-[2-(1-butyl-5-cyano-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridin-3-yl)diazen-1-yl]benzenesulfonamido}-2-[2-(5-nitro-2-oxido-3-sulfonatophenyl)diazen-1-yl]-3-sulfonatonaphthalen-1-olate)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- CRL : KBL
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Source: Charles River Stolzenseeweg 32-36 D-88353 Kisslegg
-Age at study initiation:
male: 16 weeks
females: 16 weeks
-Weight at study initiation:
male: 2.7 kg
females: 2.6 - 2.7 kg
-Housing: individually in stainless steel cages with an automatic cleaning system, equipped with feed hoppers, drinking water bowls and wood for gnawing.
-Diet: pelleted standard Kliba 341, Batch 87/94 rabbit maintenance diet ("Kliba". Klingentalmuehle AG, CH-4303 Kaiseraugst), ad libitum.
-Water: community tap water from Itingen, ad libitum.
-Acclimation period: four days
ENVIRONMENTAL CONDITIONS
-Temperature: 20 ± 3 °C
-Humidity: 40 - 70 %
-Air changes: 10-15 air changes per hour
-Photoperiod: 12 hours artificial fluorescent light (approx. 100 Lux) /12 hours dark.
-Other: music during the light period.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Remarks:
- the test item was moistened with bi-distilled water before application
- Amount / concentration applied:
- TEST MATERIAL
-Amount applied: 0.5 g - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24, 48 and 72 hours
- Number of animals:
- 1 male and 2 females
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm^2 (3.0 cm * 3.0 cm patch of surgical gauze)
- Type of wrap: the gauze was covered with a semi-occlusive dressing. The dressing was wrapped around the abdomen and anchored with an elastic bandage. The test substance was applied in such a position as to preclude oral ingestion after removal of the dressing.
REMOVAL OF TEST SUBSTANCE
- Washing: the skin was flushed with lukewarm tap water to clean the application site so that the reactions (erythema) were clearly visible at that time.
OBSERVATION TIME POINTS
The skin reactions were assessed at approximately 1, 24, 48 and 72 hours after the removal of the dressings and test substance. Moreover, viability/Mortality and Clinical Signs were observed daily during the observation period.Also body weights were observed at the start of accllmatization, on day 1 of test (application day) and at termination of observation.
SCORING SYSTEM:
Erythema and Eschar Formation
No erythema:0
Very slight erythema (barely perceptible): 1
Well defined erythema: 2
Moderate to severe erythema: 3
Severe erythema (beet redness) to slight eschar formation (injuries in depth): 4
Edema Formation
No edema: 0
Very slight edema (barely perceptible): 1
Slight edema (edges of area well defined by definite raising): 2
Moderate edema (raised approximately 1 mm): 3
Severe edema (raised more than 1 mm and extending beyond area of exposure): 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2,#3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2,#3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- CORROSION
No irreversible alteration of the treated skin was observed nor were corrosive effects evident on the skin. - Other effects:
- COLORATION
In the area of application, green staining of the treated skin by coloring of the test substance was observed.
CLINICAL SIGNS AND VIABILITY / MORTALITY
No systemic symptoms were observed in the animals during the test and observation period, and no mortality occurred.
BODY WEIGHTS
The body weight gain of all rabbits was within the normal range of variability.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- The substance is considered to be not irritating for rabbit skin.
- Executive summary:
The skin irritation test was performed to rabbit skin according to the OECD Guidelines 404 (1992) and the method B.4 of EEC-Directive 92/69 EEC. 0.5 g of the test item was topically applied onto 6 cm^2 intact dorsal skin of each of 3 young adult New Zealand rabbits. The duration of treatment was 4 hours and the scoring of skin reactions was performed 1, 24, 48 and 72 hours after removal of the dressing.
The test substance was found to be not irritant when applied to intact rabbit skin: local signs (mean values 24/48/72 hours) consisted of grade 0 erythema and grade 0 oedema in all animals. The test item caused green staining (after 1 and 24 hours) and pale green staining (after 48 and 72 hours) of the treated skin area in all animals. No corrosive effect occurred on the treated skin of any animal at any measuring interval.
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