Registration Dossier
Registration Dossier
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EC number: 234-746-5 | CAS number: 12030-88-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The following toxicokinetic information could be derived based on the physico-chemical properties and limited experimental study data with potassium superoxide.
Potassium superoxide is considered to penetrate through biological membranes as evident from an ex vivo rabbit corneal study where KO2 was demonstrated to damage endothelial cells. In absence of in vivo study data, default values of 50% oral absorption and 100% dermal absorption are assumed.
Potassium superoxide is not expected to bioaccumulate. In vivo, potassium superoxide reacts rapidly with water to produce potassium hydroxide (KOH), oxygen (O2) and potassium hydrogen peroxide (KHO2), which slowly degrades to KOH, H2O2 (hydrogen peroxide) and O2. KOH further dissociates into potassium and hydroxyl ions which constitute normal physiological ion pool. On the other hand, hydrogen peroxide is likely to degrade within a short time in in vivo conditions due to many alternative and competitive degradation pathways.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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