Registration Dossier
Registration Dossier
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EC number: 255-078-0 | CAS number: 40783-05-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- BASF-Testing method
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-(2,5-dichloro-1,4-phenylene)bis(1H-anthra[1,2-d]imidazole-6,11-dione)
- EC Number:
- 255-078-0
- EC Name:
- 2,2'-(2,5-dichloro-1,4-phenylene)bis(1H-anthra[1,2-d]imidazole-6,11-dione)
- Cas Number:
- 40783-05-9
- Molecular formula:
- C36H16Cl2N4O4
- IUPAC Name:
- 2-(2,5-dichloro-4-{6,11-dioxo-1H,6H,11H-anthra[1,2-d]imidazol-2-yl}phenyl)-1H,6H,11H-anthra[1,2-d]imidazole-6,11-dione
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Remarks:
- 50%
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- Back: 20 hours
- Observation period:
- 24 hours, 8 days
- Number of animals:
- no data
- Details on study design:
- TEST SITE
- Area of exposure: back
SCORING SYSTEM:
Erythema and Edema
Ø - no effect
(+) - questionable
+ - mild
++ - moderate
+++ - marked
N - necrosis
Sch - scabbing
Na - scar
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Slight redness occurred within the first 24 h after the the treatment but disappered within 8 days. No signs of corrosion observed.
- Other effects:
- Yellow staining observed within 24 h.
Slight scabbing observed at day 8.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance did not cause any significant signs of irritation on rabbit skin.
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