Mercaptoacetic acid

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

publication

Title:

Some aspects of the absorption, distribution and excretion of sodium thioglycolate

Author:

Freeman MV, Draize JH and Smith PK

Year:

1956

Bibliographic source:

J Pharmacol exp Ther, 118, 304-308

Materials and methods

Objective of study:

excretion

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Sodium mercaptoacetate

EC Number:

206-696-4

EC Name:

Sodium mercaptoacetate

Cas Number:

367-51-1

Molecular formula:

C2H4O2S.Na

IUPAC Name:

sodium sulfanylacetate

Details on test material:

Test compound: sodium thioglycolate labeled with S35
CAS no.: 367-51-1
Source: Tracerlab, Inc
Batch: no data
Radiochemical activity: 0.66 mc per mM
Radiochemical purity: no data

Radiolabelling:

yes

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

water

Control animals:

yes, concurrent no treatment

Details on study design:

In studies using 6 rats, 24-hour urine collections were made following  intraperitoneal administration of 2.5% aqueous labelled sodium  thioglycolate (12.5-75 mg/kg body weight)

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:

Of the total sulphur administered, significant levels were excreted as  inorganic sulphate (23-72%); the total labelled sulphur excreted during  the first 24 hours was 59-96% of the dose. Two of the rats excreted 9% or  11% on the second day and 2% or 6% on the third day respectively. No  hydrogen sulphide was detected in exhaled air during any of three 10-hour  tests on 1 rat (weight and strain not stated) treated intraperitoneally  with 150 mg sodium thioglycolate/kg bodyweight.

Metabolite characterisation studies

Metabolites identified:

no

Applicant's summary and conclusion

Executive summary:

The urinary excretion of sodium thioglycolate was also evaluated in rats (weight and strain not stated) injected i.p. with 12.5 to 75.0 mg/kg of a 2.5% solution of sodium³⁵S-thioglycolate. Urine was collected over a period of 24 h. Quantities of inorganic sulphate excreted, expressed as % of administered radioactivity, ranged from 23 to 72%. The total labelled sulphur excreted during the first 24 hours was 59-96% of the dose. Two of the rats excreted 9% or 11% on the second day and 2% or 6% on the third day respectively.