Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-08-28 to 2017-10-09
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7-dimethyloctanal
EC Number:
227-810-9
EC Name:
3,7-dimethyloctanal
Cas Number:
5988-91-0
Molecular formula:
C10H20O
IUPAC Name:
3,7-dimethyloctanal
Specific details on test material used for the study:
TEST MATERIAL
Name ( stated on the report) : TETRAHYDRO CITRAL
Appearance: Colourless to pale yellow liquid
Batch: SC00019145
Stable under storage conditions until: 18 March 2018 (expiry date)

Results and discussion

Water solubility
Key result
Water solubility:
24.4 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
4.3

Applicant's summary and conclusion

Conclusions:
The water solubility of TETRAHYDRO CITRAL was determined to be: 24.4 mg/L (20 °C, pH 4.3)
Executive summary:

The water solubility of TETRAHYDRO CITRAL (batch: SC00019145) was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6 from 2017-08-28 to 2017-09-01 at Noack Laboratorien, 31157 Sarstedt, Germany.

The solubility of the test item TETRAHYDRO CITRAL was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C.

The analytical method (GC-MS, external standard with internal standard normalisation) for the determination of the test item TETRAHYDRO CITRAL was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.

The water solubility was calculated based on the results of the samples with the two longest incubation times (48 and 72 h).

The water solubility of TETRAHYDRO CITRAL was determined to be: 24.4 mg/L (20 °C, pH 4.3)