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EC number: 203-930-7 | CAS number: 112-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Apr - 13 Jun 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildesheim, Hildesheim, Germany
- Specific details on test material used for the study:
- TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: the test material was melted at 30 - 50 °C until it was completely dissolved. 47.5 mg test item were weighed and 5 mL silicone oil were added. Mixture was vortexed and homogenized. 250 mL inoculated test medium was filled in brown glass bottles and 500 µL test item - silicone oil stock solution was pipetted directly into the inoculated test medium. - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: municipal sewage treatment plant, Hildesheim, Germany
-Pretreatment: activated sludge was washed twice with chlorine free tap water. Thereafter settled sludge was resuspended in mineral salts medium and was aerated for 2 h. Sludge was then homogenized with a blender. After sedimentation the supernatant was decanted and maintained in an aerobic condition by aeration with air for 5 d.
- Concentration of sludge: 10 mL/L were used to initiate inoculation
- Initial cell/biomass concentration: approx. 1.13 x 10^7 CFU/L in the final test solution - Duration of test (contact time):
- 60 d
- Initial conc.:
- 19 mg/L
- Based on:
- test mat.
- Initial conc.:
- 52.8 mg/L
- Based on:
- ThOD
- Initial conc.:
- 2.78 other: mg O2/mg
- Based on:
- ThOD
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral salts medium according to OECD 301 F
- Test temperature: 20 - 21 °C
- pH: 7.60 - 7. 90
- pH adjusted: no
- Concentration of sludge: 10 mL/L were used to initiate inoculation
- Continuous darkness: yes
- Other: continuous stirring
TEST SYSTEM
- Number of culture flasks/concentration: 2
- Measuring equipment: OxiTop® measuring heads, WTW Stirring platform, WTW
- Test performed in closed vessels: yes
- Details of trap for CO2: a rubber sleeve with soda lime was hung into the opening of the bottles to absorb evolved CO2
- Other: separate replicates of test item and toxicity control were prepared for measurement of pH at test start
SAMPLING
- Sampling frequency: 1080 measuring points during the 60 d incubation period
CONTROL AND BLANK SYSTEM
- Inoculum control: 2
- Inoculum control with silicone oil: 2 (500 µL silicone oil were pipetted directly into the inoculated test medium)
- Toxicity control: 1
- Functional control: 1
- Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 45 mg/L
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 57
- Sampling time:
- 28 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 65
- Sampling time:
- 60 d
- Details on results:
- - Reference substance: 100% degradation after 23 d (pass level of > 60% was reached after 3 d)
- Toxicity control: 75% degradation after 28 d (82% degradation after 60 d) - Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- A biodegradation study according to OECD 301F resulted in a biodegradation of 57% after 28 d and 65% after 60 d.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification below and the overall justification for grouping of substances attached in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 57
- Sampling time:
- 28 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 65
- Sampling time:
- 60 d
- Details on results:
- - Reference substance: 100% degradation after 23 d (pass level of > 60% was reached after 3 d)
- Toxicity control: 75% degradation after 28 d (82% degradation after 60 d)
Referenceopen allclose all
Both test item replicates reached the 10% biodegradation level on day 4. The 60% pass level was reached by the mean of replicates on day 39. The mean biodegradation on day 60 was 65%.
Table 1: % biodegradation over time
[d] | Functional Control | Biodegradation [%] | Toxicity Control | |
Test item | ||||
1 | 2 | |||
1 | 7 | 0 | 0 | 4 |
2 | 50 | 0 | 0 | 31 |
3 | 62 | 3 | 1 | 37 |
4 | 73 | 16 | 14 | 43 |
5 | 79 | 26 | 25 | 48 |
6 | 82 | 31 | 29 | 52 |
7 | 84 | 35 | 34 | 55 |
8 | 86 | 38 | 35 | 58 |
9 | 88 | 40 | 38 | 61 |
10 | 89 | 42 | 40 | 62 |
11 | 90 | 42 | 42 | 63 |
12 | 91 | 44 | 42 | 64 |
13 | 93 | 45 | 44 | 65 |
14 | 93 | 46 | 44 | 66 |
15 | 94 | 47 | 45 | 67 |
16 | 96 | 48 | 46 | 68 |
17 | 97 | 49 | 48 | 69 |
18 | 98 | 51 | 49 | 70 |
19 | 98 | 52 | 50 | 70 |
20 | 99 | 52 | 50 | 71 |
21 | 98 | 52 | 50 | 71 |
22 | 99 | 52 | 52 | 72 |
23 | 100 | 53 | 52 | 72 |
24 | 100 | 54 | 52 | 73 |
25 | 100 | 54 | 52 | 74 |
26 | 100 | 56 | 53 | 74 |
27 | 100 | 60 | 53 | 74 |
28 | 100 | 60 | 54 | 75 |
29 | 100 | 64 | 53 | 75 |
30 | 100 | 64 | 53 | 76 |
31 | 100 | 63 | 52 | 75 |
32 | 100 | 63 | 53 | 76 |
33 | 100 | 64 | 53 | 77 |
34 | 100 | 64 | 52 | 77 |
35 | 100 | 64 | 52 | 77 |
36 | 100 | 65 | 54 | 77 |
37 | 100 | 65 | 54 | 78 |
38 | 100 | 65 | 54 | 78 |
39 | 100 | 66 | 54 | 78 |
40 | 100 | 66 | 53 | 79 |
41 | 100 | 66 | 54 | 79 |
42 | 100 | 67 | 54 | 79 |
43 | 100 | 67 | 53 | 79 |
44 | 100 | 66 | 53 | 79 |
45 | 100 | 67 | 54 | 80 |
46 | 100 | 68 | 53 | 80 |
47 | 100 | 68 | 54 | 80 |
48 | 100 | 68 | 55 | 80 |
49 | 100 | 68 | 55 | 80 |
50 | 100 | 68 | 55 | 81 |
51 | 100 | 68 | 55 | 80 |
52 | 100 | 69 | 54 | 81 |
53 | 100 | 70 | 54 | 81 |
54 | 100 | 70 | 54 | 81 |
55 | 100 | 70 | 54 | 81 |
56 | 100 | 70 | 54 | 81 |
57 | 100 | 69 | 55 | 81 |
58 | 100 | 70 | 57 | 81 |
59 | 100 | 70 | 58 | 81 |
60 | 100 | 71 | 58 | 82 |
Description of key information
Trichloro(octadecyl)silane (CAS 112-04-9) is inherently biodegradable (57% after 28 d and 65% after 60 d, OECD 301F) based on read across from CAS 18643-08-8
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
Additional information
There are no data on biodegradation for trichloro(octadecyl)silane (CAS 112-04-9). In accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 “Grouping of substances and read across” and in accordance with the read across assessment framework (RAAF, ECHA 2017) a read across from the analogue substance octadecyldimethylchlorosilane (CAS 18643-08-8) has been applied to support the environmental hazard assessment of the substance. Details on the read across justification can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.
The available study (2016) investigating the biodegradation of the analogue substance octadecyldimethylchlorosilane (CAS 18643-08-8) was conducted according to OECD guidance 301F and GLP conditions. The inoculum (non-adapted activated sludge from a sewage treatment plant) was exposed for 60 days to 19 mg/L test substance and biodegradation was calculated based on CO2 evolution. The substance reached a biodegradation value of 57% after 28 d and 65% after 60 d. Therefore, the read across substance is considered as inherently biodegradable.
Based on the results of the analogue substance, trichloro(octadecyl)silane (CAS 112-04-9) is assumed to be inherently biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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