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Diss Factsheets
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EC number: 203-930-7 | CAS number: 112-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No studies were available to assess the skin or eye irritation potential
of the registered substance, however, data are available for the
structural ananlogue substances trimethoxymethylsilane (CAS: 1185-55-3)
and triethoxymethylsilane (CAS: 2031-67-6), respectively.
WoE approach:
CAS: 1185-55-3 and CAS: 2031-67-6 (according to OECD TG 404): not
irritating to the skin
CAS: 1185-55-3 and CAS: 2031-67-6 (according or similar to OECD TG 405):
not irritating to the eye
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Details on read across justifications can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.
The available studies for skin and eye irritation with the structural analogue substance trimethoxymethylsilane (CAS 1185-55-3) were conducted in accordance with the appropriate test guidelines and to GLP (Hazelton France, 1992b and Kreiling and Jung, 1991). Trimethoxymethylsilane was found to be not irritating to rabbit skin or eyes, although mild effects were observed.
The available skin irritation study on the structural analogue substance triethoxymethylsilane (CAS 2031-67-6) which was conducted in compliance with GLP and in accordance with OECD TG 404, found the substance to be a transient, mild irritant in rabbits. However, the results obtained in this study were not sufficient for classification as a skin irritant (Hazelton France, 1992b). Furthermore, an eye irritation study on the structural analogue substance triethoxymethylsilane (CAS 2031-67-6) which was not in compliance with GLP, but was equivalent or similar to OECD TG 405, showed that triethoxy(methyl)silane was not irritating to rabbit eyes. Only minor, transient eye irritation was observed following instillation of the test material into the eyes of six rabbits. The Draize score of 0.06 out of 13 indicates that triethoxymethylsilane would not be considered irritating to the eyes of rabbits (Bushy Run Research Center, 1981c). All the studies are in agreement of the lack of skin and eye irritation potential of the structural analogue substances, trimethoxymethylsilane and triethoxymethylsilane. This therefore strengthens the overall assumption that the registered substance, dimethoxydimethylsilane, will not be a skin or eye irritant.
Justification for classification or non-classification
The available data on Irritation / Corrosion of the structural analogue substances, trimethoxymethylsilane and triethoxymethylsilane, respectively, do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification of the registered substance.
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