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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 November 2016 to 18 January 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Remarks:
modified
Key result
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
20 °C
pH:
>= 8 - <= 8.8
Remarks on result:
other: miscible in all proportions

TABLE 10 – SAMPLE CONCENTRATIONS, OBSERVATIONS AND SOLUTION pH

Sample

Concentration (% w/w)

Observations

Solution pH

1

5.1

Clear, colourless, single phase liquid with no visible excess, undissolved test item

8.0

2

25.0

Clear, slightly straw coloured, single-phase liquid with no visible excess, undissolved test item

8.3

3

50.1

Clear, straw coloured, single phase liquid with no visible excess, undissolved test item

8.5

4

74.7

Clear, straw coloured, single phase liquid with no visible excess, undissolved test item

8.7

5

94.9

Clear, straw coloured, single phase liquid with no visible excess, undissolved test item

8.8

Overall result: Miscible in all proportions at 20.0 ± 0.5 °C

Conclusions:
The test item was determined to be miscible with water in all proportions at 20.0 ± 0.5 °C.
Executive summary:

GUIDELINE

The determination was carried out by visual assessment, using a modified flask method designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The test item was determined to be miscible with water in all proportions at 20.0 ± 0.5 °C.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26 October 2016 to 15 November 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Remarks:
modified
Key result
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
>= 10.8 - <= 11.3
Remarks on result:
other: miscible in all proportions

TABLE 2 – SAMPLE CONCENTRATIONS, OBSERVATIONS AND SOLUTION pH

Sample

Concentration (% w/w)

Observations

Solution pH

1

5.2

Clear, colourless, single-phase liquid with no visible excess, undissolved test item

10.8

2

25.1

Clear, colourless, single-phase liquid with no visible excess, undissolved test item

11.0

3

49.7

Clear, colourless, single-phase liquid with no visible excess, undissolved test item

11.2

4

74.5

Clear, colourless, single-phase liquid with no visible excess, undissolved test item

11.3

5

94.9

Clear, colourless, single-phase liquid with no visible excess, undissolved test item

11.3

Overall result: Miscible in all proportions at 20.0 ± 0.5 °C

Executive summary:

GUIDELINE

The determination was carried out by visual assessment, using a modified flask method designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The test item was determined to be miscible with water in all proportions at 20.0 ± 0.5 °C.

Description of key information

The research material and the product as manufactured were determined to be miscible in all proportions at 20.0 ± 0.5 °C by visual assessment using a modified flask method (OECD 105 and EU Method A.6).

Key value for chemical safety assessment

Additional information

GUIDELINE

The determinations were carried out by visual assessment, using a modified flask method designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

 

RESULTS

The research material and the product as manufactured were determined to be miscible with water in all proportions at 20.0 ± 0.5 °C.