Registration Dossier
Registration Dossier
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EC number: 200-735-9 | CAS number: 70-47-3
Endpoint summary
Administrative data
Description of key information
No data available, no testing justified, for further details please refer to "attached justification for data waiving".
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Acute oral toxicity studies as well as irritation studies, tests on mutagenicity and repeated dose toxicity indicate that the toxicological potential of L-asparagine is low. L-asparagine is a naturally, ubiquitously occurring amino acid which is an integral part of the intermediary metabolism. Hence, in vivo testing is scientifically not justified. Furthermore, due to its size and its minor capacity of reacting electrophilic it is considered to be out of the applicability domain of the validated and accepted in chemico/in vitro test systems currently available.
Based on available information, L-asparagine does not need to be classified and labelled according to Regulation (EC) No 1272/2008 (CLP) and the Globally Harmonized System for Classification and Labeling of Chemicals (GHS) with respect to skin sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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