Isotridecan-1-ol

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Principles of method if other than guideline:

BASF-Test: The test substance was administered into the peritoneal cavity of male and female mice to detect the acute toxicity.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Reference substance 001

EC Number:

607-896-8

Details on test material:

- Name of test material (as cited in study report): Tridecanol (mixture of branched aliphatic alcohols)
- Physical state: liquid

Test animals

Species:

mouse

Strain:

other: Tuebinger

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: mean: 29 g

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

other: aqueous emulsion with traganth

Details on exposure:

VEHICLE
- Concentration in vehicle: 20, 8 or 2 %

Doses:

1.6 ml/kg bw, 0.8 ml/kg bw, 0.4 ml/kg bw, 0.2 ml/kg bw (= 1349 mg/kg bw, 674 mg/kg bw, 337 mg/kg bw, 169 mg/kg bw; calculated by means of the density: 843 g/l at 20°C)

No. of animals per sex per dose:

5 animals per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days (1.6 ml/kg bw, 0.8 mg/kg bw and 0.4 mg/kg bw), 7 days (0.2 ml/kg bw)
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 500 mg/kg bw

Based on:

test mat.

Remarks on result:

other: The original citation was LD50 = ca. 0.6 ml/kg bw; calculation in mg/kg bw by means of the density: 843 g/l at 20°C

Mortality:

- after 14 days:
1.6 ml/kg bw: 5/5 (died between 48 h and 14 days after administration);
0.8 ml/kg bw: 4/5 (died between 7days and 14 days after administration);
0.4 ml/kg bw: 1/5 (died within 48 h after administration);
0.2 ml/kg bw: 0/5 (observation finished 7 days after administration);

Clinical signs:

- on the day of administration: quiet behaviour, high stepping gait, staggering, accelerated respiration, convulsion (from time to time);
- 1 day after administration till 6 days after administration: gaunt flanks, accelerated and intermittent respiration, piloerection, abdominal position (sporadic)
In part, the survivors were not without findings until day 7 after administration.

Body weight:

no data

Gross pathology:

3 killed animals: slight agglutination of the organs in the peritoneal cavity
other animals: organs without findings