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Key value for chemical safety assessment

Additional information

Genotoxicity was evaluated in bacterial and mammalian cell assays. The Ames test yielded a clear positive result whereas the Mouse Lymphoma Assay showed no genotoxic effects. The chromosomal aberration assay performed in mammalian cells assay did not show a clastogenic effect.

The appraisal that Ziram should not be classified as genotoxic is confirmed by three in-vivo assays, two micronucleus assays in murine blood and bone marrow and a cytogenetic assay in murine spermatogonia. All assays were clearly negative.


Short description of key information:
Thiram was mutagenic in bacteria, but negative in mammalian test systems, including in-vivo assays.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The appraisal that Ziram should not be classified as genotoxic is confirmed by three in-vivo assays, two micronucleus assays in murine blood and bone marrow and a cytogenetic assay in murine spermatogonia. All assays were clearly negative.