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EC number: 214-987-2 | CAS number: 1241-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1968
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 100 males and 100 female subjects were exposed twice (13 days rest period between treatment) for 48 hours on the upper arm using an occluded patch (impregnated paper). Skin reactions were scored at 0, 24 and 48 hours after removal of the patch to determine the sentising potential of the test substance.
- GLP compliance:
- no
- Type of study:
- patch test
- Justification for non-LLNA method:
- Human study available
Test material
- Reference substance name:
- 2-ethylhexyl diphenyl phosphate
- EC Number:
- 214-987-2
- EC Name:
- 2-ethylhexyl diphenyl phosphate
- Cas Number:
- 1241-94-7
- Molecular formula:
- C20H27O4P
- IUPAC Name:
- 2-ethylhexyl diphenyl phosphate
- Details on test material:
- - Name of test material (as cited in study report): Santicizer 141
- Physical state: Liquid
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Strain:
- other: Not relevant
- Sex:
- male/female
- Details on test animals and environmental conditions:
- Not relevant, human study
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- Unknown (applied as received)
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- Unknown (applied as received)
- No. of animals per dose:
- 200 human subjects
- Details on study design:
- Not relevant, human study
- Challenge controls:
- Not relevant, human study
- Positive control substance(s):
- not required
- Remarks:
- human study
Results and discussion
- Positive control results:
- Not relevant, human study
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- other: all readings after induction
- Group:
- test chemical
- Dose level:
- Not available
- No. with + reactions:
- 30
- Total no. in group:
- 200
- Clinical observations:
- Score of 1: 18 subjects, score of 2: 12 subjects
- Remarks on result:
- other: Reading: other: all readings after induction. Group: test group. No with. + reactions: 30.0. Total no. in groups: 200.0. Clinical observations: Score of 1: 18 subjects, score of 2: 12 subjects.
- Remarks:
- Dose levels not available
- Key result
- Reading:
- other: all readings after challenge
- Group:
- test chemical
- Dose level:
- Not available
- No. with + reactions:
- 29
- Total no. in group:
- 200
- Clinical observations:
- Score of 1: 18 subjects, score of 2: 11 subjects
- Remarks on result:
- other: Reading: other: all readings after challenge. Group: test group. No with. + reactions: 29.0. Total no. in groups: 200.0. Clinical observations: Score of 1: 18 subjects, score of 2: 11 subjects.
- Remarks:
- Dose levels not available
Any other information on results incl. tables
30 out of 200 subjects (20 female) showed positive skin reactions at 1 of the 3 readings after induction. At the challenge phase, 29 out of 200 subjects (again 20 female) showed a positive skin reaction at 1 of the 3 readings. Only 1 human subject showed an additional positive skin reaction at the challenge readings, while in 2 other subjects the reaction disappeared.
Due to the high level of skin reactions after the induction phase (comparable to that in de challenge phase), the substance can be considered rather irritating than sensitising.
The reactions on the skin cleared without incident within 10 days after removal of the patch.
Applicant's summary and conclusion
- Interpretation of results:
- ambiguous
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this study, it was not possible to conclude on the sensitising potential of Santicizer 141, as the substance can be considered rather irritating than sensitising.
- Executive summary:
100 males and 100 female subjects were exposed twice (15 days rest period) for 48 hours on the upper arm using an occluded patch (impregnated paper). Skin reactions were scored at 0, 24 and 48 hours after removal of the patch to determine the sensitising potential of the test substance.
30 out of 200 subjects showed positive skin reactions at 1 of the 3 readings after induction. At the challenge phase, 29 out of 200 subjects showed a positive skin reaction at 1 of the 3 readings. Only 1 human subject showed an additional positive skin reaction at the challenge readings, while in 2 other subjects the reaction disappeared.
Under the conditions of this study, it was not possible to conclude on the sensitising potential of Santicizer 141, as the substance can be considered rather irritating than sensitising.
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