7-Isopropyl-2H,4H-1,5-benzodioxepin-3-one

Density

Link to relevant study record(s)

Reference

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From December 1 to 12, 2008

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised with its purity. Full validation applies with minor restrictions due to temperature (liquid state).

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

1995

Deviations:

yes

Remarks:

test conducted at temperature 40 °C

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

2008

Deviations:

yes

Remarks:

test conducted at temperature 40 °C

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

Swiss GLP compliance programme (inspected on November 15 and 16, 2006 / signed on March 29, 2007)

Type of method:

oscillating densitimeter

Specific details on test material used for the study:

Storage condition of test material: Refrigerator (between 0 and 10 °C under nitrogen)

Dynamic viscosity of test material:

no data

Key result

Type:

relative density

Density:

1.119 other: relative density has no dimension

Temp.:

40 °C

Determination 1: 1.119 at 40°C

Determination 2: 1.119 at 40°C

Determination 3: 1.119 at 40°C

Conclusions:

The test substance, as melted, is denser than water.

Executive summary:

The relative density of the test substance was measured under GLP according OECD 109 / EU A3 guideline, oscillating densitimeter method.

After suitable calibration using two reference substances, a melted sample was measured in triplicate at 40 °C.

The relative density of the test substance under liquid form has been determined to be 1.119 at 40 ±0.5 °C.

Description of key information

Measured relative density = 1.119 at 40°C (melted substance)

The substance is denser than water.

Additional information

A reliable experimental study, conducted according to a recognized OECD/EU method and under GLP, is available. Despite minor restriction due to measuring temperature, it is considered as a key study, but the result is not retained as key data, as not relating to ambient temperature.