Registration Dossier
Registration Dossier
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EC number: 202-800-7 | CAS number: 99-91-2
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: mixed culture, consisting of an Arthrobacter sp. and a Micrococcus sp.
- Details on inoculum:
- - Source of inoculum/activated sludge: Soil samples of different origins (forest, field, and compost) as well as river sediment samples (Rhine and Lippe) were mixed for enrichment cultures containing 4-chloroacetophenone as the sole source of carbon and energy.
- Pretreatment: Cells were washed twice with and then resuspended in phosphate buffer to give an optical density at 546 nm of 8 to 9. Then, 25 ml of the cell suspensions was incubated in sealed, fluted 100-ml Erlenmeyer flasks. - Duration of test (contact time):
- 72 h
- Details on study design:
- TEST CONDITIONS
- Test temperature: 30°C
TEST SYSTEM
- Culturing apparatus: 100 mL Erlenmeyer flasks containing 25 ml of medium. - Interpretation of results:
- other:
- Conclusions:
- The biodegradation pathway of 4-chloroacetophenone was investigated. 4-Chlorophenyl acetate, 4-chlorophenol, and 4-chlorocatechol were identified as metabolites.
Reference
4-Chlorophenyl acetate, 4-chlorophenol, and 4-chlorocatechol were identified as metabolites through comparison of retention times and UV spectra with those of standard substances.
A mixed culture consisting of an Arthrobacter sp. and a Micrococcus sp. was able to grow with 4-chloroacetophenone as a sole source of carbon and energy.
Description of key information
The biodegradation pathway of 4-chloroacetophenone was investigated. 4-Chlorophenyl acetate, 4 -chlorophenol, and 4-chlorocatechol were identified as metabolites.
A conclusion about ready biodegradability cannot be drawn.
Key value for chemical safety assessment
Additional information
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