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Diss Factsheets
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EC number: 402-470-6 | CAS number: 87172-89-2 CINEOLE ALCOHOL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- GLP compliance:
- yes
Test material
- Reference substance name:
- (1S,2S)-1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptan-2-ol
- Cas Number:
- 87172-89-2
- IUPAC Name:
- (1S,2S)-1-methyl-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptan-2-ol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: The test substance was stored in the dark at ambient temperature
FORM AS APPLIED IN THE TEST
Preparation of the test substance for formulation: The test substance as received was contained in a narrow necked vessel. Before being used for formulation purposes all of the test substance was melted in an oven at 70 °C, well mixed, and then sub-sampled into smaller vessels. One of these sub-samples was submitted to the Analytical Chemistry Division for analysis.
Formulation of the test substance: The test substance was supplied as a ground up solid for the skin irritancy test. Grinding was carried out using a pestle and mortar.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Rabbits were obtained from Sittingbourne Research Centre Breeding unit.
- Age at study initiation: 4 - 9 months
- Weight at study initiation: Males: 3486 to 4124 g; Females: 4560 to 4868 g
- Housing: The animals were singly housed in hanging, stainless-steel cages with perforated dimple or all-mesh floors, all mesh tops and half-mesh fronts; each cage mesured 67 cm x 43 cm x 45 cm. The cages were mounted in three rows of two on a single-sided rack (total of six cages).
- Diet: Standard Rabbit Diet, S.Q.C., Special Diet Services Ltd., Essex; provided ad libitum by means of a top-loading food hopper
- Water: Water (filtered but untreated from public supply) was provided ad libitum by means of an automatic valve-regulated drinking line.
- Acclimation period: At least two weeks.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-19 °C
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 250 mg (this dose equating the largest dose that could practicably be used)
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 7 days
- Number of animals:
- 6 (3 animals per sex)
- Details on study design:
- TEST SITE
- Area of exposure: 2 cm x 2 cm
- Type of wrap if used: The test powder and surrounding skin were covered by a single layer of gauze and held in place by means of an elastic adhesive bandage.
REMOVAL OF TEST SUBSTANCE
- Washing: Yes. After 4 hours the wrapping and patch were removed and the test site washed with water and gently dried.
- Time after start of exposure: 4h
OBSERVATION TIME POINTS: 30 min, 24h, 48h, 72h and 7 days
SCORING SYSTEM: See table 1 for details.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4, 24, 48, 72 h and 7d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: See table 2 for detailed information
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4, 24, 48, 72 h and 7d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: See table 2 for detailed information
Any other information on results incl. tables
Table 2: Primary irritation of semi-occluded rabbit skin after a single application of the test item (4 hours exposure)
Animal No & sex |
Response |
4 hours |
24 hours |
48 hours |
72 hours |
7 days |
937 M |
Erythema |
0 |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
0 |
|
934 M |
Erythema |
0 |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
0 |
|
935 M |
Erythema |
0 |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
0 |
|
917 F |
Erythema |
0 |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
0 |
|
920 F |
Erythema |
0 |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
0 |
|
915 F |
Erythema |
0 |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
0 |
|
Mean Erythema score |
0 |
0 |
0 |
0 |
0 |
|
Mean Oedema score |
0 |
0 |
0 |
0 |
0 |
Scale:
Erythema readings 0 = No erythema to 4 = Beet redness
Oedema readings 0 = No oedema to 4 = Severe oedema
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.