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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 November, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method, and under GLP. Test substance is adequately specified. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Commission Regulation (EC) No 761/2009 of 23. July 2009, published on 24. Aug. 2009
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected on 13 and 14 October 2014 / signed on 08 April 2015
Type of method:
static method
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
762 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
927 Pa

Table 4.6/2: Calculated values for 1/T and log P

n                  

Temperature T (°C)

Pressure P (hPa)

Temperature T (K)

1/T (1/K)

log P

log Pa

1

20.1

8.1

293.15

0.00341006

2.9085

2

27.9

9.6

301.05

0.00332171

2.9823

3

36.0

13.4

309.15

0.00323468

3.1271

4

44.6

18.8

317.75

0.00314713

3.2742

5

52.0

25.7

325.15

0.00307550

3.4099

6

43.4

18.2

316.55

0.00315906

3.2601

7

34.6

13.0

307.75

0.00324939

3.1139

8

26.8

9.2

299.95

0.00333389

2.9638

9

19.8

8.0

292.95

0.00341355

2.9031

10

14.7

6.3

287.85

0.00347403

2.7993

linear regression :

y = -1485.016933 x + 7.947895044

r² = 0.986285894  (> 0.95)

Table 4.6/3: Calculated Values for vapour pressure

Parameter

Value

Vapour Pressure (20 °C)

762 Pa

Vapour Pressure (25 °C)

927 Pa

 

The vapour pressure of the test item was measured using the static method as described in EU method A.4. Ten pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 762 Pa at 20.0 °C and 927 Pa at 25 °C. The values of the heating and cooling down phase showed good correspondence.

Therefore, the result of the study is considered valid.

Conclusions:
The vapour pressure of the test item was calculated as 762 Pa at 20.0 °C and 927 Pa at 25 °C (interpolation).
These values represent the components with the highest vapour pressure.
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, static method. Ten pairs temperature/vapour pressure were used to calculate a regression in a temperature range of 14.7 – 52.0 °C, from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 762 Pa at 20.0 °C and 927 Pa at 25 °C.

These values represent the components with the highest vapour pressure.

Description of key information

The vapour pressure of the test item was calculated as 762 Pa at 20.0 °C and 927 Pa at 25 °C (interpolation).

These values represent the components with the highest vapour pressure.

Key value for chemical safety assessment

Vapour pressure:
762 Pa
at the temperature of:
20 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study.