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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2013-11-28
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
2008
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
2004
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.76
Temp.:
22.6 °C
Remarks on result:
other: No information for pH
Details on results:
No information for pH

Calibration Data of the Reference Items:

Reference item

Retention time

Mean retention time

Log Kow

2-Butanone

2.212

2.217

2.215

0.3

Benzyl alcohol

2.779

2.788

2.784

1.1

Benzonitrile

3.890

3.902

3.896

1.6

Methyl benzoate

7.326

7.329

7.328

2.1

Atrazine

7.863

7.866

7.865

2.6

Chlorobenzene

14.949

14.962

14.956

2.8

Phenyl benzoate

27.379

27.384

27.382

3.6

 

Conclusions:
The log Pow of THFMA is reported to be 1.76 ± 0.08 at 22.6°C.
Executive summary:

The n-Octanol/Water partition coefficient (log Pow) of THFMA was determined according to OECD Guideline 117 (2004) and EU method A.8 (2008) using the HPLC method. The log Pow was 1.76 ± 0.08 at 22.6°C.

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.

Description of key information

The n-Octanol/Water partition coefficient (log Kow) of THFMA was determined to be 1.76 ± 0.08 at 22.6°C (OECD Guideline 117/EU Method A.8; HPLC method).

Key value for chemical safety assessment

Log Kow (Log Pow):
1.76
at the temperature of:
22.6 °C

Additional information

The n-Octanol/Water partition coefficient (log Kow) of THFMA was determined according to OECD Guideline 117 (2004) and EU method A.8 (2008) using the HPLC method. The log Kow was 1.76 ± 0.08 at 22.6°C.