Registration Dossier
Registration Dossier
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EC number: 234-165-7 | CAS number: 10576-12-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Handbook
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Acute inhalation toxicity study of 2-methoxy-2-methylpropane (1634-04-4) in rat.
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set, 2012
- Reference Type:
- other: authoritative database
- Title:
- Acute inhalation toxicity study of 2-methoxy-2-methylpropane (1634-04-4) in rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity study for 2-methoxy-2-methylpropane (1634-04-4) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- tert-butyl methyl ether
- EC Number:
- 216-653-1
- EC Name:
- tert-butyl methyl ether
- Cas Number:
- 1634-04-4
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-Methoxy-2-methylpropane
- Details on test material:
- Name - 2-methoxy-2-methylpropane
InChI - 1S/C5H12O/c1-5(2,3)6-4/h1-4H3
Smiles - CC(C)(C)OC
- Molecular formula (if other than submission substance):C5H12O
- Molecular weight (if other than submission substance):88.1488 g/mole
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- Name - 2-methoxy-2-methylpropane
InChI - 1S/C5H12O/c1-5(2,3)6-4/h1-4H3
Smiles - CC(C)(C)OC
- Molecular formula (if other than submission substance):C5H12O
- Molecular weight (if other than submission substance):88.1488 g/mole
- Substance type:Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Remarks on duration:
- not specified
- Concentrations:
- 23576 ppm (23576000 mg/m3)
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 23 576 000 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 23576 ppm
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute inhalation toxicity study in rat by using 2-methoxy-2-methylpropane (1634-04-4) for exposure of 4 hours was considered to be 23576 ppm (23576000 mg/m3).
- Executive summary:
The acute inhalation toxicity study was conducted by using 2-methoxy-2-methylpropane (1634-04-4) in rat at the concentration of 23576 ppm.50% mortality was observed at 23576 ppm, when exposed for 4 hours.Therefore, LC50 was considered to be 23576 ppm (23576000 mg/m3), when rat was treated with 2-methoxy-2-methylpropane by inhalation.
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