Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 278-169-7 | CAS number: 75277-39-3
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
The adsorption coefficient of the read across source substance was determined according to the HPLC-method described in guideline 67/548/EEC, annex C.19 and OECD 121 (2001). The Log Koc was determined as 0.010 and lies outside the range of the reference items (range: 1.32 - 5.63). Therefore the log Koc of the source substance is stated as < 1.32.
Key value for chemical safety assessment
- Koc at 20 °C:
- 1.32
Additional information
No experimental data on the adsorption behaviour of the registration substance is available, but information of a GLP-compliant guideline study with the read across source substance HEPES (CAS no. 7365-45-9).
A GLP-adsorption study according to OECD 121 (2001) was performed with the read across source substance using a HPLC with a cyanopropyl chemical bound resin on a silica base column. Six reference items with different retention times were used to produce a calibration curve, since retention time on cyanopropyl columns and Koc are correlated. The reference items were chosen on behalf of the retention time of the test item on the column. First, a solution of the reference items was analysed three times with HPLC, then a solution of the test item (three times) and finally three more times the solution with the references. For each reference item, the capacity factor k’ was calculated from the retention time of sodium nitrate and the retention time of the respective reference item. A calibration function was set up using the literature values for Koc of the reference items and the mean capacity factor of the six determinations. In the graph Log k’ versus Log Koc, linear regression was performed, giving r2= 0.9989. The chromatogram of the test item gave one peak (mean RT = 2.085 min). With the help of the calibration, the Log Koc was determined as 0.010 and lies outside the range of the reference items (range: 1.32 – 5.63). Therefore the log Koc of the source substance is stated as < 1.32.
Conclusion
Based on reliable data for the read across source substance the log Koc of the target substance is considered < 1.032.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
