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EC number: 604-667-4 | CAS number: 14898-67-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an OECD guideline study, the acute oral LD50 value for ruthenium trichloride hydrate was determined to be 595 mg/kg bw in rats (Berthold, 1993).
No relevant acute dermal or inhalation toxicity data were identified.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 April - 14 May 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study conducted according to GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- (guideline deleted 17-Dec-2002)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- (obsolete)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Bor: WISW (SPFCpb)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Versuchstierzucht GmbH & Co. KG., D-33176 Borchen
- Age at study initiation: Males 8 weeks, females 9 weeks
- Weight at study initiation: Males 172-224 g, females 155-186 g
- Fasting period before study: ~16 hours
- Housing: Macrolon cages type II, soft wood granulate HW 300/500W animal bedding, 1/cage
- Diet (e.g. ad libitum): Standard diet, Ssnif(R) special diet for rats, ad libitum
- Water (e.g. ad libitum): Drinking water quality, automatic drinking water system with drinking nipples, ad libitum
- Acclimation period: >=5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.5 - 22.5
- Humidity (%): 39 - 68
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: 28-Apr-1993 To: 14-May-1993 - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 100, 215 and 464 mg/ml
- Amount of vehicle (if gavage): 2.15 ml/kg bw
- Justification for choice of vehicle: No data, but standard vehicle
- Lot/batch no. (if required): No data
- Purity: No data, but deionized water
MAXIMUM DOSE VOLUME APPLIED: 2.15 ml/kg bw
DOSAGE PREPARATION (if unusual): Aqueous solutions were prepared by shaking immediately before dosing
CLASS METHOD (if applicable): Not applicable - Doses:
- 215, 464 and 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
- Behaviour, general condition and clinical signs: continuously for 4-6 hours after dosing, then once daily
- Mortality: twice daily on working days, otherwise once daily
- Body weight: at start of study and on day 7 and 14 or after death
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - yes, body weight - yes, organ weights - no, histopathology - no, other - no - Statistics:
- Probit analysis for LD50 and 95% confidence limits
- Preliminary study:
- None
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 723 mg/kg bw
- 95% CL:
- >= 379 - <= 1 131
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 525 mg/kg bw
- 95% CL:
- >= 272 - <= 1 095
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 595 mg/kg bw
- 95% CL:
- >= 444 - <= 808
- Mortality:
- Males: 215 and 464 mg/kg bw , 0/5 deaths in each group; 1000 mg/kg bw, 5/5 deaths (1 at 24 hours, 2 at 2 days and 2 at 3 days);
Females: 215 mg/kg bw, 0/5 deaths; 464 mg/kg bw, 2/5 deaths (1 at 3 days and 1 at 9 days); 1000 mg/kg bw, 5/5 deaths (1 at 24 hours, 2 at 2 days, 1 at 3 days and 1 at 4 days) - Clinical signs:
- other: 215 mg/kg bw: in all animals, sunken sides, slight hypokinesia; in 2/10 rats stilted/restrained gait; recovery by 24 hours in 9/10 and after 8 days in 1/10; 464 mg/kg bw: in most animals sunken sides, slight hypokinesia, stilted gait, piloerection; in ind
- Gross pathology:
- 464 mg/kg bw: surviving animals - thickened stomach wall, red brown foci/masses in the mucosa
464 and 1000 mg/kg bw; deceased animals - liquid in abdominal and thoracic cavities, black contents in dilated stomachs, hardened intestinal tissue, reddened viscera, discoloured stomach mucosa with focal haemorrhages - Other findings:
- - Organ weights: Not done
- Histopathology: Not done
- Potential target organs: Not done
- Other observations: Not done - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In a guideline study, to GLP, the acute oral LD50 value for ruthenium (III) chloride hydrate was determined to be 595 mg/kg bw in rats.
- Executive summary:
The acute toxicity of ruthenium (III) chloride hydrate was investigated in rats, in an OECD Test Guideline 401 study, conducted according to GLP. Animals (5/sex/group) were administered the test substance (in water) by oral gavage at doses of 215, 464 or 1000 mg/kg bw, and observed for up to 14 days.
There were no deaths in the low dose group, while two females died in the mid-dose group and all animals died at the highest tested dose. Clinical signs of toxicity were seen in all treated animals. Gross pathology indicated effects in the stomach mucosa at the higher two doses. The acute oral LD50 was determined (using probit analysis) to be 723 mg/kg bw in male rats (95% CI 379-1131 mg/kg bw), 525 mg/kg bw in females (95% CI 272-1095 mg/kg bw) and 595 mg/kg bw for both sexes combined (95% CI 444-808 mg/kg bw).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 595 mg/kg bw
- Quality of whole database:
- Overall, good-quality database which meets REACH Standard Information Requirements.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No relevant acute toxicity human data were identified.
The acute toxicity of ruthenium (III) chloride hydrate was investigated in rats, in an OECD Test Guideline 401 study, conducted according to GLP. Animals (5/sex/group) were administered the test substance (in water) by oral gavage at doses of 215, 464 or 1000 mg/kg bw, and observed for up to 14 days. There were no deaths in the low dose group, while two females died in the mid-dose group and all animals died at the highest tested dose. Clinical signs of toxicity were seen in all treated animals. Gross pathology indicated effects in the stomach mucosa at the higher two doses. The acute oral LD50 was determined (using probit analysis) to be 723 mg/kg bw in male rats (95% CI 379-1131 mg/kg bw), 525 mg/kg bw in females (95% CI 272-1095 mg/kg bw) and 595 mg/kg bw for both sexes combined (95% CI 444-808 mg/kg bw) (Berthold, 1993).
No relevant acute dermal or inhalation toxicity data were identified. However, acute toxicity testing by a second route is not considered appropriate as ruthenium trichloride hydrate is considered corrosive.
Justification for classification or non-classification
Based on the results of the available acute oral rat study, ruthenium trichloride hydrate should be classified for acute oral toxicity (category 4) according to EU CLP criteria (EC 1272/2008).
No clear evidence of specific target organ toxicity was noted. As such, classification for STOT-SE is not considered appropriate.
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