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EC number: 946-322-3
CAS number: -
* Examinations were performed within the first 30 minutes and 1, 2, 3
and 5 hours after treatment.
No clinical signs were evident in any animal during the acclimatization
Body weight are presented in grams
S: Scheduled necropsy
The purpose of this study was to assess the acute toxicity of the test
substance when administered by a single oral gavage to rats, followed by
an observation period of 14 days.
Two groups, each of three female HanRcc:WIST (SPF) rats, were treated
with the test item by oral gavage administration at a dosage of 2000
mg/kg body weight. The
test item was diluted in vehicle (corn oil) at a concentration of 0.2
g/mL and administered at a dosing volume of 10 mL/kg.
The animals were examined daily during the acclimatization period and
mortality, viability and clinical signs were recorded.
All animals were examined for clinical signs within the first 30 minutes
and approximately 1, 2, 3 and 5 hours after treatment on day 1 and once
daily during test days 2-15. Mortality/viability was recorded at
approximately 30 minutes, 1, 2, 3 and 5 hours after administration on
test day 1 (with the clinical signs) and twice daily during days 2-15.
Body weights were recorded on day 1 (prior to administration) and on
days 8 and 15. All animals were necropsied and examined macroscopically.
All animals survived until the end of the study period.
No clinical signs were observed during the course of the study.
The body weight of the animals was within the range commonly recorded
for this strain and age.
No macroscopic findings were recorded at necropsy.
The median lethal dose of the test item after single oral administration
to female rats, observed over a period of 14 days is:
LD50 (female rat): greater than 2000 mg/kg body weight
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