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EC number: 244-168-5 | CAS number: 21041-95-2
Cadmium compounds have been shown to induce genetic changes both in vitro and in vivo. There is considerable evidence to suggest that that the primary mechanism of genotoxicity is based upon the production of oxidative lesions.On the assumption of an oxidative mechanism for the genotoxicity of cadmium compounds we can predict that there may be thresholds of genotoxicity at low doses where DNA repair enzymes remove lesions thus reducing the potential for genetic changes in cells and animals.
However, there are some studies which indicate that cadmium compounds inhibit repair activity which may limit activity within potential thresholded regions of the dose response curve.
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