Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
other: Review
Adequacy of study:
weight of evidence
Reliability:
other: Not applicable
Rationale for reliability incl. deficiencies:
other: Review of existing genotoxicity data on cadmium and cadmium compounds by Prof. Parry, SAFECHEM Independent Consultants in Genetic and Molecular Toxicology, UK
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
review article or handbook
Title:
A review of the genotoxicity of cadmium compounds
Author:
Parry JM and Parry EM
Year:
2009
Bibliographic source:
Review conducted for the International Zinc Association

Materials and methods

Type of study / information:
Review of existing studies on in vitro and in vivo genotoxicity of cadmium
Principles of method if other than guideline:
Not applicable

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Not applicable

Results and discussion

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
Cadmium compounds have been shown to induce genetic changes both in vitro and in vivo. There is considerable evidence to suggest that that the primary mechanism of genotoxicity is based upon the production of oxidative lesions.On the assumption of an oxidative mechanism for the genotoxicity of cadmium compounds we can predict that there may be thresholds of genotoxicity at low doses where DNA repair enzymes remove lesions thus reducing the potential for genetic changes in cells and animals.

However, there are some studies which indicate that cadmium compounds inhibit repair activity which may limit activity within potential thresholded regions of the dose response curve.
Executive summary:

Cadmium compounds have been shown to induce genetic changes both in vitro and in vivo. There is considerable evidence to suggest that that the primary mechanism of genotoxicity is based upon the production of oxidative lesions.On the assumption of an oxidative mechanism for the genotoxicity of cadmium compounds we can predict that there may be thresholds of genotoxicity at low doses where DNA repair enzymes remove lesions thus reducing the potential for genetic changes in cells and animals.

However, there are some studies which indicate that cadmium compounds inhibit repair activity which may limit activity within potential thresholded regions of the dose response curve.