Registration Dossier
Registration Dossier
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EC number: 226-285-3 | CAS number: 5343-92-0
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Reference Type:
- secondary source
- Title:
- HYDROLITE-5 SURVEY OF SAFETY STUDIES
- Author:
- Symrise
- Year:
- 2 003
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Symrise
- Year:
- 2 005
- Bibliographic source:
- MSDS - 616751 HYDROLITE-5
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Repeated Insult Patch Test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Pentane-1,2-diol
- EC Number:
- 226-285-3
- EC Name:
- Pentane-1,2-diol
- Cas Number:
- 5343-92-0
- Molecular formula:
- C5H12O2
- IUPAC Name:
- pentane-1,2-diol
- Details on test material:
- - Name of test material (as cited in study report): Hydrolite-5
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 60 male and female volunteers. 53 subjects completed the study
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: semiocclusive
- Vehicle / solvent: water
- Concentrations: 50%
- Volume applied: 0.2 ml
- Testing/scoring schedule: for induction 9 application for 24 hin 3 weeks; for challenge two weeks after last induction for 24 h
EXAMINATIONS
- Grading/Scoring: 24 h and 72 aftre patch removal
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0/53
- Number of subjects with negative reactions: 53/53
None of the panelists reacted throughout the experiment. Hydrolite-5 was ver wy ell tolerated by the skin.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
