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EC number: 204-671-2 | CAS number: 124-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Diallylamine [124-02-7]: Review of Toxicological Literature
- Author:
- US National Toxicology Program
- Year:
- 1 997
- Bibliographic source:
- US National Toxicology Program
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were administered, by gavage, a single dose of diallylamine.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diallylamine
- EC Number:
- 204-671-2
- EC Name:
- Diallylamine
- Cas Number:
- 124-02-7
- Molecular formula:
- C6H11N
- IUPAC Name:
- diallylamine
Constituent 1
- Specific details on test material used for the study:
- Purity not provided.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Female and male rats were administered, by gavage, a sinlge dose of diallylamine.
- Doses:
- Females: 215, 464, 1000 and 4640 mg/k (2.21, 4.78, 10.29 and 47.76 mmol/kg)
Males: 215, 464, 1000 and 2150 (2.21, 4.78, 10.29 and 22.13 mmol/kg) - No. of animals per sex per dose:
- 5 females and 5 males per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Frequency of observations not stated. No details on weights available.
- Necropsy of survivors performed: Not specified.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 316 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 205 - <= 488
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 501 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 344 - <= 730
- Mortality:
- Females: No observable effects occurred at the lowest tested dose (215 mg/kg), while mortality was induced at higher doses within 20 hours of dosing.
Males: At lower doses, death sometimes occurred a week or later after dosing, while at 1000 mg/kg and higher, all male rats died within 2 hours.
Mortality
215 MG/KG (1/5M, 0/5F),
464 MG/KG (4/5M, 2/5F),
1000 MG/KG (5/5M, 5/5F),
2150 MG/KG (5/5M).
4640 MG/KG (5/5F). - Clinical signs:
- Females: No observable effects occurred at the lowest dose (215 mg/kg).
Males: Rats exhibited a dose-dependent depression (lethargy) in all exposed groups.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Rat acute oral LD50 for diallylamine reported lowest value of 316 mg/k (3.25 mmol/kg) for males and 501 mg/kg (5.16 mmol/kg) for females.
- Executive summary:
Female Sprague-Dawley rats were administered, by gavage, a single dose of diallylamine at 215, 464, 1000 and 4640 mg/k (2.21, 4.78, 10.29 and 47.76 mmol/kg).
No observable effects occurred at the lowest tested dose, while mortality was induced at higher doses within 20 hours of dosing.
In the same study, male Sprague-Dawley rats administered diallylamine at 215, 464, 1000 and 2150 (2.21, 4.78, 10.29 and 22.13 mmol/kg) exhibited a dose-dependent depression (lethargy) in all exposed groups. At lower doses, death sometimes occurred a week or later after dosing, while at 1000 mg/kg and higher, all male rats died within 2 hours.
Based on the results of the study the following LD50 values were reported: 316 mg/k (3.25 mmol/kg) for males and 501 mg/kg (5.16 mmol/kg) for females.
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