Registration Dossier
Registration Dossier
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EC number: 233-311-7 | CAS number: 10114-47-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study report contains the limited information on the test conditions because the study has been performed in 1988. However available information is sufficient to conclude on the classification of the substance. Further the test was performed on the vertebrates and use of results from old experimental studies is one of the options to provide information requested by REACH. New experimental studies with vertebrates must only be conducted if there is no adequate existing information.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Disodium 2,2'-(azodi-p-phenylene)bis[6-methylbenzothiazole-7-sulphonate]
- EC Number:
- 233-311-7
- EC Name:
- Disodium 2,2'-(azodi-p-phenylene)bis[6-methylbenzothiazole-7-sulphonate]
- Cas Number:
- 10114-47-3
- Molecular formula:
- C28H20N4O6S4.2Na
- IUPAC Name:
- disodium 2,2'-(diazene-1,2-diyldi-4,1-phenylene)bis(6-methyl-1,3-benzothiazole-7-sulfonate)
- Reference substance name:
- Sodium chloride
- EC Number:
- 231-598-3
- EC Name:
- Sodium chloride
- Cas Number:
- 7647-14-5
- Molecular formula:
- ClNa
- IUPAC Name:
- sodium chloride
- Test material form:
- solid: particulate/powder
- Details on test material:
- Trade name: Saturnová žluť LFFBatch No.: 69/88Solubility in water: 24 g/l
Constituent 1
impurity 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Weight at study initiation: 130 - 170 g
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE - Concentration in vehicle: 20 % w/w
- Doses:
- 6.310, 7.943 and 10.00 g/kg
- No. of animals per sex per dose:
- 10 animals per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days - Necropsy of survivors performed: yes - Other examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 8 420 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 7 745 - < 9 155
- Mortality:
- 6.310 g/kg: 0/107.943 g/kg: 3/1010.00 g/kg: 9/10
- Clinical signs:
- other: 6.310 g/kg: Without any clinical sights of intoxication.7.943 g/kg: Mild diarrhea, languidness. From the 2nd day without any clinical sights of intoxication.10.00 g/kg: Mild diarrhea, languidness. From the 2nd day without any clinical sights of intoxicati
- Gross pathology:
- Dead and killed animals: without macroscopic organ changes.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not classified according to GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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