Registration Dossier
Registration Dossier
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EC number: 210-716-7 | CAS number: 621-95-4
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 4,4'-ethylenedianiline
- EC Number:
- 210-716-7
- EC Name:
- 4,4'-ethylenedianiline
- Cas Number:
- 621-95-4
- Molecular formula:
- C14H16N2
- IUPAC Name:
- 4-[2-(4-aminophenyl)ethyl]aniline
- Details on test material:
- purity: 99.8%
Constituent 1
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 2.25
- Temp.:
- 23 °C
- pH:
- > 7.7 - < 8.6
- Details on results:
- Results in detail:
determ. no. stock solution water test substance test substance
[ml] [ml] conc. in octanol conc. in water Log Pow
A1 5 10 754,2 4,0 2,28
A2 5 10 769,5 4,0 2,29
B1 10 10 764,5 4,4 2,24
B2 10 10 768,8 4,4 2,24
C1 20 10 786,8 4,7 2,23
C2 20 10 774,3 4,7 2,22
mean --- --- --- --- 2,25
recovery rate: 96 - 100%
UV/VIS spectroscopy:
The absorption of the phases was measured at 247 nm after appropriate dilution.
Applicant's summary and conclusion
- Conclusions:
- The Log Pow in n-octanol/water is 2.25 at 23°C.
- Executive summary:
The partition coefficient LogPow (n-octanol/water) of the substance was determined according to OECD guideline 107 with the shake flask method.
It was found to be 2.25 at 23°C
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