Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Oral:
- male rats, LD50: 1259 mg/kg bw
- rats, LD50: 2000 mg/kg bw (study not reliable)
- rats, LD50: 467 mg/kg bw (study not reliable)
- mice, LD50: 250 mg/kg bw (study not reliable)
- mice, LD50: 1670 mg/kg bw (study not reliable)
- rabbits, LD50: 1500 mg/kg bw (study not reliable)
Inhalation:
- male/female rats, LC50: 1.53 mg/L
Dermal:
- dogs, LD50: > 2000 mg/kg bw
- cats, LD50: < 2000 mg/kg bw
-  rats, LD50:  500 mg/kg bw (study not reliable)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
1 259 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
1 530 mg/m³ air

Additional information

A number of reliable studies plus supporting information are available in multiple species for the acute oral and inhalation toxicity of 2,4 -Xylidine. The lowest reliable oral LD50determined was 1259 mg/kg bw for male Osborne-Mendel rats. The LC50 (4-hour) for 2,4-Xylidine was established at 1.53 mg /L. All results are shown in the “Short description of key information” field

Justification for classification or non-classification

Due to the findings described above (LD50 oral in rats 1259 mg/kg bw, LC50 inhalation in rats1.53 mg/L) 2,4 -Xylidine has to be classified as

- acute orally toxic: Xn, R22 - harmful if swallowed; Hazard category 4, H302 - harmful if swallowed

- toxic by inhalation: T, R23 - toxic by inhalation; Hazard category 2, H330 - fatal if inhaled

according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).

For precautionary reasons the annex VI classification to Regulation (EC) No 1272/2008

- acute orally toxic: T, R25 - toxic if swallowed; Hazard category 3, H301 - toxic if swallowed

- acute dermal toxic: T, R24 - toxic in contact with skin ; Hazard category 3, H311 - toxicin contact with skin

is followed.