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EC number: 946-212-5
CAS number: -
Acute toxicity to freshwater fish: No toxicity observed even at highest concentration level tested.RA_CAS68608-26-4_OECD 203_ Oncorhynchus mykiss: LL50(96h) > 100 mg/L WAF,RA_CAS115733-09-0_OECD 203_Oncorhynchus mykiss: LL50(96h) > 100 mg/L WAFAcute toxicity to saltwater fish: No toxicity observed even at highest concentration level tested.RA_CAS70024-71-4_OECD 203_Cyprinodon variegatus: LL50 (96h) > 10000 mg/L WAF,RA_CAS61789-86-4_OECD 203_Cyprinodon variegatus: LL50 (96h) > 10000 mg/L WAF
acute toxicity to fish was investigated for different analogues
structures of the C20-24 sodium sulfonate (Benzenesulfonic
acid, mono-C20-24 (even)-sec-alkyl derivs., para-, sodium salts).
For the substance itself, no experimental data are available. Since all
substances used belong to the same chemical group, aryl-alkyl
sulfonates, the same behaviour and toxicity potential can be expected.
Sodium sulfonate read-across substance (CAS 68608-26-4), calcium
sulfonate read-across substance (CAS 61789 -86 -4), calcium sulfonate
read-across substance (CAS 115733-09-0) and calcium sulfonate
read-across substance (CAS 70024-71-4) were used to fulfil the endpoint
of short-term toxicity to freshwater fish. For the detailed procedure of
the read-across principle and justifications, please refer to the
separate Read-Across Statement (Chemservice S.A., 2016).
toxicity to freshwater fish
96-hour key study, juvenile Rainbow trouts (Oncorhynchus mykiss)
were exposed to the sodium sulfonate read-across substance (CAS 68608
-26-4) at nominal concentrations of 0 (control group) and 100 mg/L WAF
loading rate under semi-static conditions (Goodband, 2005a).
experiment was conducted in accordance to OECD Guideline 203 and under
GLP compliance. Based on the intrinsic properties of the used substance,
Water Accommodated Fractions (WAFs) were prepared for testing.
Physico-chemical parameters (i.e. water temperature, pH and dissolved
oxygen concentration (DOC)) were recorded daily throughout the test
duration of 96 h. No mortalities and no sublethal effects were noted at
the highest tested concentration, thus the LL50(96h) is reported to be >
100 mg/L WAF with a corresponding NOELR of 100 mg/L WAF.
second key study (Goodband, 2005b), calcium sulfonate read-across
substance (CAS 115733 -09 -0) was tested under same test conditions
(i.e. Rainbow trout; 96 h exposure according to OECD Guideline 203;
single concentration level of 100 mg/L WAF). Again, no toxic effects
were observed at this concentration level. Hence, the LL50(96h) is > 100
mg/L WAF, whereas NOELR amounts to 100 mg/L WAF.
toxicity to saltwater fish
minnow) was used as saltwater representative fish in an experiment in
order to determine the toxicity potential of the calcium sulfonate
read-across substance(CAS 70024-71-4) in a key study by Nicholson
(1986b). The acclimatisation period was about 13 days and the biomass
loading rate was 0.056 g/L. A control group was included and a single
concentration of 10000 mg/L WAF was applied (limit test). The exposure
time was 96 h. Sodium lauryl sulfate was used as reference substance,
revealing a LC50 (96h) of 1.2 mg/L. Neither in the control nor in any of
the treatment groups, mortality or signs of toxicity were recorded.
Therefore, the LL50 (96h) is > 10000 mg/L WAF with a corresponding NOELR
of 10000 mg/L WAF. No statistical analysis of data was warranted due to
the fact that the test substance was found to be non-toxic under the
another key study (Nicholson, 1986a), calcium sulfonate read-across
substance (CAS 61789-86-4) was tested under same test conditions (i.e. Sheepshead
minnow; 96 h exposure according to OECD Guideline 203; single
concentration level of 10000 mg/L WAF). Again, no toxic effects were
observed at this concentration level. Hence, the LL50(96h) is > 10000
mg/L WAF, whereas NOELR amounts to 10000 mg/L WAF.
toxic effects observed in all acute fish studies even at the highest
concentration levels tested.The weight-of-evidence indicates that the
lower NOECs for O. mykiss are not an indicator of toxicity per
se, but are the result of dose selection.
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