Registration Dossier
Registration Dossier
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EC number: 203-506-1 | CAS number: 107-59-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity data submissions
- Author:
- Parent, R.A.
- Year:
- 2 000
- Bibliographic source:
- International Journal of Toxicology, 19(5):331-373
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- tert-butyl chloroacetate
- EC Number:
- 203-506-1
- EC Name:
- tert-butyl chloroacetate
- Cas Number:
- 107-59-5
- Molecular formula:
- C6H11ClO2
- IUPAC Name:
- tert-butyl chloroacetate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 237 g (m), 200 g (f)
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 200, 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: presumably daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathological changes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 414 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 200-1000 mg/kg bw: 0%
2000 mg/kg bw: 100% - Clinical signs:
- other: At 200 and above local inflammation and/or incrustations were seen at the application site. Vocalization and increased motility were noticed at 2000 mg/kg bw. Onset of symptoms was on day 1. On day 7 signs had disappeared. Deaths occurred within 8 h post-
- Gross pathology:
- Necropsy of dead animals showed reddening of the lungs and injection of the subcutaneous vessels at the application site. No pathological changes were seen at final necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The approximate acute dermal LD50 for male and female rats is 1414 mg/kg bw (geometric mean between 1000 and 2000 mg/kg bw)
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