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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
fish, juvenile growth test
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
Not applicable, calculated value
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance.
Justification for type of information:
Tha aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitionning of the hydrocarbons between the water and organism.
Qualifier:
no guideline followed
Principles of method if other than guideline:
Tha aquatic toxicity was estimated by a QSAR, the Petrotox computer model. This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitionning of the hydrocarbons between the water and organism.
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No test surrogate nor analogue material
Analytical monitoring:
not required
Details on sampling:
Not applicable (calculated data)
Vehicle:
no
Details on test solutions:
Not applicable (calculated data)
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Not applicable (calculated data)
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Post exposure observation period:
Not applicable (calculated data)
Hardness:
Not applicable (calculated data)
Test temperature:
Not applicable (calculated data)
pH:
Not applicable (calculated data)
Dissolved oxygen:
Not applicable (calculated data)
Salinity:
Not applicable (calculated data)
Nominal and measured concentrations:
Not applicable (calculated data)
Details on test conditions:
Not applicable (calculated data)
Reference substance (positive control):
no
Key result
Duration:
28 d
Dose descriptor:
NOELR
Effect conc.:
0.116 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Details on results:
No details
Results with reference substance (positive control):
No reference substance
Reported statistics and error estimates:
Not applicable

No other information

Validity criteria fulfilled:
yes
Conclusions:
The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is 0.116 mg/l based on growth.
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is 0.116 mg/l based on growth.

 

Description of key information

The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is 0.116 mg/l based on growth.

Key value for chemical safety assessment

Additional information

The aquatic toxicity was estimated using the Petrotox computer model (v. 3.04), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is 0.116 mg/l based on growth.