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Diss Factsheets
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EC number: 279-919-6 | CAS number: 82205-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The potential of the source substance (87.9% purity) to cause skin sensitisation reactions following topical application to the skin of CBA/JN mice, was assessed using the LLNA: BrdU-ELISA method (OECD 442B). An increase in cell proliferation of draining lymph nodes was observed in the high, medium and low dose groups, indicating that the test item may elicit a sensitisation response.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
No data is available for the target substance. Thus, available data from the source substance was used in a read-across approach. Details on the read-across rational are provided in section 13.
The potential of the source substance (87.9% purity) to cause skin sensitisation reactions following topical application to the skin of CBA/JN mice, was assessed using the LLNA: BrdU-ELISA method (OECD 442B). Based on the results from a preliminary test the test item was topically administered at concentrations of 50, 25 and 10% w/w, in acetone:olive oil 4:1 (v/v) in the main assay. No mortality nor clinical signs were recorded in any animal. Changes in body weight observed during the study were within the expected range for this strain and age of animals. An increase in cell proliferation of draining lymph nodes was observed in the high, medium and low dose groups with Stimulation Indices of 3.07, 4.77 and 4.64, respectively. Dunnett’s test showed a statistically significant difference (p < 0.01) between medium and low dose groups and negative control group, indicating that the test item may elicit a sensitisation response.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In a dermal sensitization study according to OECD 442B, female mice were tested positive for the source substance. Based on the results from the read-across partner, classification of the target substance is warranted (Skin Sens. 1, H317). Subcategorization into 1A/1B is not possible as the EC3 value could not be determined as the stimulation indices of all concentrations were above 3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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