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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study according to OECD and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Indate (2-), hexachlorododeca-µ-methoxy-µ6-oxohexa-, hydrogen, compd. with N-methylmethanamine (1:2:2)
- Cas Number:
- 1381802-10-3
- Molecular formula:
- [In6O(OMe)12Cl6]2–[NH2Me2]+2 · 2MeOH
- IUPAC Name:
- Indate (2-), hexachlorododeca-µ-methoxy-µ6-oxohexa-, hydrogen, compd. with N-methylmethanamine (1:2:2)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Batch number V107 – V110
Purity > 99 %
Molecular weight 1446.302 g/mol
Appearance Colorless, crystalline powder
Water solubility Reacts (sensitive to hydrolysis, t ½ (pH 7): approx. 5 minutes
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- The tested limit concentration of 100 mg/L of the test item iXsenic S Gen 3.4 and the control were analytically verified at the start of the exposure (0 h) and at the end of the exposure (48 h).
Test solutions
- Vehicle:
- no
- Details on test solutions:
- A stock solution (100 mg/L of the test item were weighed out) was freshly prepared with dilution water.
The test item dispersion was stirred with a magnetic stirrer (approx. 1100 rpm) at room temperature for 2 h. Since the test item is known to hydrolyse quickly (t1/2 pH 7: approx. 5 min), the reaction products were tested.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna STRAUS (Clone 5) was used as test organisms.
20 daphnids, divided into 4 replicates, each with 5 daphnids per limit concentration and control were tested. 2 to 24 h old daphnids were used for the study. They were obtained by removing the parental daphnids twice within 22 h. Daphnids were left for acclimatisaion for at least 2 h in dilution water.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- During the test the incubator temperature was 19 – 20 °C.
- pH:
- Nominal
test item
concentration pH-value
[mg/L] 0h 48h (replicate 1-4)
100 7.10 7.69 7.63 7.60 7.56
Control 7.75 7.57 7.69 7.71 7.70 - Dissolved oxygen:
- Nominal
test item
concentration Dissolved O2-concentration [mg/L]
[mg/L] 0h 48h (replicate 1-4)
100 7.90 8.49 8.46 8.49 8.51
Control 8.17 7.91 8.19 8.16 8.23 - Nominal and measured concentrations:
- Measured TOC Concentrations in the Definitive Test
Sampling date 2013-06-05 2013-06-07
Start of the exposure, 0 End of the exposure, 48 h
Start of analysis 2013-06-05 2013-06-07
Nominal
test item
concentration
[mg/L] Total Organic Carbon (TOC)*
Measured concentration#[mg/L] Measured concentration# [mg/L] %
100 15.2 16.2 107
Control < 2.00 < 2.00 — - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- EC50: 1.66 mg/L (CI 1.48 - 2.01 mg/L)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- At the limit concentration of 100 mg/L of the test item, no effects were observed on Daphnia magna.
- Executive summary:
In the acute immobilisation test with Daphnia magna (STRAUS), the effects of the limit concentration of 100 mg/L of the test item were determined according to OECD 202 (2004) and Council Regulation (EC) No. 440/2008 Method C.2 (2008). The limit test was conducted under static conditions over a period of 48 hours.
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