Registration Dossier
Registration Dossier
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EC number: 421-720-5 | CAS number: 18085-02-4 3,4-DIACETOXY-1-BUTENE
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data migrated from NONS with permission to refer granted by ECHA.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-diacetoxybut-3-ene
- EC Number:
- 421-720-5
- EC Name:
- 1,2-diacetoxybut-3-ene
- Cas Number:
- 18085-02-4
- Molecular formula:
- C8H12O4
- IUPAC Name:
- 1-(acetyloxy)but-3-en-2-yl acetate
- Test material form:
- liquid
- Details on test material:
- No information on test material available. Endpoint study information provided by ECHA from migrated NONS data and specific information not included.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 794 mg/kg bw
- Based on:
- not specified
- 95% CL:
- >= 483 - <= 1 305
- Mortality:
- 2000 mg/kg bw: 5/5
1000 mg/kg bw: 2/5 - Gross pathology:
- No treatment-related macroscopic effects observed
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- in accodance with CLP regulation (1272/2008/EC, as amended))
- Conclusions:
- Based on data provided by ECHA, the acute oral LD50 value is 794 mg/kg bw.
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