Bis(2-chloroethyl) ether

Henry's Law constant

Link to relevant study record(s)

Reference

Endpoint:

Henry's law constant

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

no guideline available

Principles of method if other than guideline:

- Principle of test: Equilibrium Partitioning in Closed Systems (EPICS)
- Short description of test conditions: measurement of multiple pairs of high/low volume closed systems to obtain several independent estimates of Henry's law constant.

GLP compliance:

not specified

Specific details on test material used for the study:

TEST MATERIAL
- Names (as cites): bis(2-chloroethyl)ether
- Purity: > 99%

H:

0.001 atm m³/mol

Temp.:

10 °C

H:

0 atm m³/mol

Temp.:

15 °C

Key result

H:

0.001 atm m³/mol

Temp.:

20 °C

H:

0 atm m³/mol

Temp.:

25 °C

H:

0 atm m³/mol

Temp.:

30 °C

TEMPERATURE REGRESSION EQUATION:

The data generated from this study were used to to generate temperature regression equations based on the theoretical constant-pressure temperature dependence of Henry's law constant. The "enthalpy of volatilization" is assumed constant over the entire temperature range in the regression, even though such a simplification may not always be physically realistic.

The temperature regression parameters and error bands (at 25°C) for Bis(2-chloroethyl) ether is provided below:

Temperature regression			95% confidence interval
Slope	Intercept	Fit (R^2)	Lower (%)	Upper (%)
1.5763E+04	-6.2146E+01	0.6716	-86.83	659.06

The fit of the linear regression was moderate. This may originate from a nonlinear Henry's law constant behavior or from high coefficient of variation (COV) of replicates measurement at a given temperature (see below).

HENRY'S LAW CONSTANT MEASUREMENTS:

High coefficient of variation (COV) of replicates measurement were observed for Bis(2 -chloroethyl) ether. However, this result is not suprising as Henry's Law constant values for the test substance are low and thus measurement variability (expressed in COV) is logically higher. Henry's constants at various temperature and associated COV are reported below:

Temperature	Henry's Constant (atm m^3/mol)	Coefficient of variation (%)
10°C	124.75E-05	75.96
15°C	16.58E-05	347.46
20°C	72.04E-05	28.41
25°C	12.53E-05	92.84
30°C	1.38E-05	697.60

Conclusions:

Henry's constant for Bis(2-chloroethyl) ether was determined to be 72.04E-05  atm m3/mol at 20°C.

Executive summary:

In this well documented study from the Engineering & Services Laboratory of the Tyndall Air Force Base (U.S.A.), Henry's law constant of Bis(2-chloroethyl) ether was measured at various temperature (10-30°C) based Equilibrium Partitioning in Closed Systems (EPICS). Appropriate control procedure were in place to ensure data reliability. Henry's constant for Bis(2-chloroethyl) ether was determined to be 72.04E-05  atm m3/mol at 20°C.

The report has been subjected to a formal review process. Accordingly, it has been assigned a reliability score of 2.

Description of key information

In this well documented study from the Engineering & Services Laboratory of the Tyndall Air Force Base (U.S.A.), Henry's law constant of Bis(2-chloroethyl) ether was measured at various temperature (10-30°C) based Equilibrium Partitioning in Closed Systems (EPICS). Appropriate control procedure were in place to ensure data reliability. Henry's constant for Bis(2-chloroethyl) ether was determined to be 72.04E-05  atm m3/mol at 20°C.

The report has been subjected to a formal review process. Accordingly, it has been assigned a reliability score of 2.

Key value for chemical safety assessment

Henry's law constant (H) (in Pa m³/mol):

72.99

at the temperature of:

20 °C