Registration Dossier
Registration Dossier
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EC number: 221-816-5 | CAS number: 3244-88-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from secondary source
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid , and Alkyl Aryl Sulfonate Hydrotropes as used in Cosmetics
- Author:
- Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, Ronald Hill, Daniel Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen
- Year:
- 2 011
- Bibliographic source:
- Int J Toxicol. 2011 Dec;30(6 Suppl):270S-83S.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of Sodium xylenesulphonate was performed in rat.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- Sodium xylenesulphonate
- EC Number:
- 215-090-9
- EC Name:
- Sodium xylenesulphonate
- Cas Number:
- 1300-72-7
- Molecular formula:
- C8H10O3S.Na
- IUPAC Name:
- sodium 3,4-dimethylbenzenesulfonate
- Test material form:
- solid
- Details on test material:
- IUPAC Name: Sodium xylenesulphonate
Common name: sodium xylenesulphonate
Mol. Formula: C24H27Na3O9S3
Mol. Weight: 208.2121 g/mol
Smiles notation: S(=O)(=O)(c1cc(c(cc1)C)C)[O-].[Na+]
InChIKey: QUCDWLYKDRVKMI-UHFFFAOYSA-M
Substance type: organic
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- IUPAC Name: Sodium xylenesulphonate
Common name: sodium xylenesulphonate
Mol. Formula: C24H27Na3O9S3
Mol. Weight: 208.2121 g/mol
Smiles notation: S(=O)(=O)(c1cc(c(cc1)C)C)[O-].[Na+]
InChIKey: QUCDWLYKDRVKMI-UHFFFAOYSA-M
Substance type: organic
Physical State: Solid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 7200 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 7 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality was observed
- Mortality:
- 50 % mortality was observed
- Clinical signs:
- other: Erythema with additional desquamation was observed
- Gross pathology:
- At necropsy, focal or multifocal red discoloration and desquamation of the treated skin were noted
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The LD50 was considered to be 7200 mg/kg bw when rats were treated with Sodium xylenesulphonate (CAS no. 1300-72-2) by dermal application.
- Executive summary:
Acute dermal toxicity study was done in rats using test material Sodium xylenesulphonate (CAS no. 1300-72-2). 50% Mortality was observed at dose 7200 mg/kg bw.Clinical signs like Erythema with additional desquamation was observed.At necropsy, focal or multifocal red discoloration and desquamation of the treated skin were noted .Hence, LD50 was considered to be7200mg/kg body weight when rat was treated with Sodium xylenesulphonate (CAS no. 1300-72-2) by dermal application.
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