N-phenyl-4-[[4-(phenylamino)phenyl][4-(phenylimino)cyclohexa-2,5-dien-1-ylidene]methyl]aniline monohydrochloride

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database

Data source

Reference

Reference 1

Reference Type:

other: authoritative database

Title:

Acute oral toxicity of 124-18-5

Author:

U.S. National Library of Medicine

Year:

2017

Bibliographic source:

ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017.

Reference 2

Reference Type:

secondary source

Title:

Toxicity of n-C9 to n-C13 alkanes in the rat on short term inhalation

Author:

Nilsen O G , Haugen O A, Zahlsen K, Halgunset J, Helseth A, Aarset H, Eide I.

Year:

1988

Bibliographic source:

Pharmacology and Toxicology Vol. 62, Pg. 259, 1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as metioned below

Principles of method if other than guideline:

Acute inhalation toxicity of Decane (CAS no: 124-18-5) in rat.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Decane

EC Number:

204-686-4

EC Name:

Decane

Cas Number:

124-18-5

Molecular formula:

C10H22

IUPAC Name:

Decane

Details on test material:

- IUPAC Name: Decane
- Mol. formula: C10H22
- Molecular Weight: 142.284 g/mole
- Smiles: C(CCCCC)CCCC
- InChI: 1S/C10H22/c1-3-5-7-9-10-8-6-4-2/h3-10H2,1-2H3

Specific details on test material used for the study:

- Name of test material (as cited in study report): Decane
- Molecular formula (if other than submission substance): C10H22
- Molecular weight (if other than submission substance): 142.284 g/mole
- Substance type: organic
- Physical state: No data
- Purity: No data
- Impurities (identity and concentrations): No data

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

not specified

Remark on MMAD/GSD:

not specified

Details on inhalation exposure:

not specified

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

Remarks on duration:

not specified

Concentrations:

1369000 mg/m3

No. of animals per sex per dose:

not specified

Control animals:

not specified

Details on study design:

not specified

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

1 369 000 mg/m³ air

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: 50% mortality was observed

Mortality:

50% mortality was observed at 1369000 mg/m3

Clinical signs:

other: not specified

Body weight:

not specified

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

The acute inhalation toxicity study in rat by using Decane for exposure of 8 hr was considered to be 1369000 mg/m3.

Executive summary:

The acute inhalation toxicity study was conducted by using Decane in Sprague Dawley rats at the concentration of1369000 mg/m3. 50% mortality was observed at 1369000 mg/m3 when exposed for 8 hours. Therefore, LC50 was considered to be1369000 mg/m3 when rats were treated with Decane by inahaltion for 8 hours.