Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 915-048-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
No intrinsic data is available on the reaction mass itself.
The classification is based on the data on the both constituents.
* Dicerium trisulphide:
28d-NOAEL (Rat, male and female) = 150 mg/kg bw/day
Based on the experimental conditions of this study, it is concluded that the oral administration of Dicerium trisulphide at a dose of 1000 mg/kg/day is associated with local irritant changes in the stomach and duo denum and with microcytic anemia. All changes showed complete or almost complete reversibility by the end of the 2-week recovery period.
Although some similar, but slight, localized microscopic changes were seen in an isolated animal dosed with 150 mg/kg/day, this dose can be considered to represent a No Observed Adverse Effect Level (NOAEL) for local effects.
* Dilanthanum trisulphide
28d-NOAEL (Rat, male and female) = 150 mg/kg bw/day
The repeated oral administration of Lanthanum sulphide at a dosage of 150 mg/kg/day for four weeks was well tolerated with no evidence of severe organ dysfunction. No significant changes were seen at the dose level of 15 mg/kg/day and this is considered to be the a No-Observed-Effect Level (NOEL) in this study.
* Reaction mass
According to the studies available on Dicerium trisulphide and Dilanthanum trisulphide, these test substances are not classified for repeated dose toxicity by oral route. Therefore, Reaction mass of dicerium trisulphide and lanthanum trisulphide is not classified for repeated dose toxicity by oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
