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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
No guideline available
GLP compliance:
no
Remarks:
study pre-dates introduction of GLP
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Citronellol
EC Number:
203-375-0
EC Name:
Citronellol
Cas Number:
106-22-9
Molecular formula:
C10H20O
IUPAC Name:
3,7-dimethyloct-6-en-1-ol
Constituent 2
Chemical structure
Reference substance name:
Geraniol
EC Number:
203-377-1
EC Name:
Geraniol
Cas Number:
106-24-1
Molecular formula:
C10H18O
IUPAC Name:
(E)-3,7-dimethylocta-2,6-dien-1-ol
Constituent 3
Chemical structure
Reference substance name:
(E)-6,10-dimethylundeca-3,9-dien-2-one
Cas Number:
19870-49-6
Molecular formula:
C12H20O
IUPAC Name:
(E)-6,10-dimethylundeca-3,9-dien-2-one
Constituent 4
Chemical structure
Reference substance name:
Dipentene
EC Number:
205-341-0
EC Name:
Dipentene
Cas Number:
138-86-3
Molecular formula:
C10H16
IUPAC Name:
1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene
Constituent 5
Chemical structure
Reference substance name:
Linalool
EC Number:
201-134-4
EC Name:
Linalool
Cas Number:
78-70-6
Molecular formula:
C10H18O
IUPAC Name:
3,7-dimethylocta-1,6-dien-3-ol
Constituent 6
Chemical structure
Reference substance name:
(±)-(1α,2β,5α)-5-methyl-2-(1-methylvinyl)cyclohexan-1-ol
EC Number:
256-557-7
EC Name:
(±)-(1α,2β,5α)-5-methyl-2-(1-methylvinyl)cyclohexan-1-ol
Cas Number:
50373-36-9
Molecular formula:
C10H18O
IUPAC Name:
rel-(1R,2S,5R)-5-methyl-2-(prop-1-en-2-yl)cyclohexanol
Constituent 7
Chemical structure
Reference substance name:
(1α,2β,4β)-1-methyl-2,4-bis(methylvinyl)-1-vinylcyclohexane
EC Number:
251-713-0
EC Name:
(1α,2β,4β)-1-methyl-2,4-bis(methylvinyl)-1-vinylcyclohexane
Cas Number:
33880-83-0
Molecular formula:
C15H24
IUPAC Name:
rel-(1R,2R,4S)-1-methyl-2,4-di(prop-1-en-2-yl)-1-vinylcyclohexane
Constituent 8
Chemical structure
Reference substance name:
(1E,6E)-8-isopropyl-1-methyl-5-methylenecyclodeca-1,6-diene
Cas Number:
105453-16-5
Molecular formula:
C15H24
IUPAC Name:
(1E,6E)-8-isopropyl-1-methyl-5-methylenecyclodeca-1,6-diene
Constituent 9
Chemical structure
Reference substance name:
rel-(1R,4aR,8aS)-1-isopropyl-4,7-dimethyl-1,2,4a,5,6,8a-hexahydronaphthalene
Cas Number:
31983-22-9
Molecular formula:
C15H24
IUPAC Name:
rel-(1R,4aR,8aS)-1-isopropyl-4,7-dimethyl-1,2,4a,5,6,8a-hexahydronaphthalene
Constituent 10
Chemical structure
Reference substance name:
rel-(1R,4aS,8aS)-1-isopropyl-7-methyl-4-methylene-1,2,3,4,4a,5,6,8aoctahydronaphthalene
Cas Number:
39029-41-9
Molecular formula:
C15H24
IUPAC Name:
rel-(1R,4aS,8aS)-1-isopropyl-7-methyl-4-methylene-1,2,3,4,4a,5,6,8aoctahydronaphthalene
Constituent 11
Chemical structure
Reference substance name:
rel-(1R,8aS)-1-isopropyl-4,7-dimethyl-1,2,3,5,6,8ahexahydronaphthalene
Cas Number:
60305-17-1
Molecular formula:
C15H24
IUPAC Name:
rel-(1R,8aS)-1-isopropyl-4,7-dimethyl-1,2,3,5,6,8ahexahydronaphthalene
Constituent 12
Chemical structure
Reference substance name:
rel-2-((1R,3S,4S)-4-methyl-3-(prop-1-en-2-yl)-4-vinylcyclohexyl)propan-2-ol
Cas Number:
23811-48-5
Molecular formula:
C15H26O
IUPAC Name:
rel-2-((1R,3S,4S)-4-methyl-3-(prop-1-en-2-yl)-4-vinylcyclohexyl)propan-2-ol
Constituent 13
Chemical structure
Reference substance name:
5,9-dimethyl-2-(6-methylhept-5-en-2-yl)deca-2,8-dienal
Cas Number:
82451-80-7
Molecular formula:
C20H34O
IUPAC Name:
5,9-dimethyl-2-(6-methylhept-5-en-2-yl)deca-2,8-dienal
Constituent 14
Reference substance name:
Likely oxygenated constituent
IUPAC Name:
Likely oxygenated constituent
Constituent 15
Reference substance name:
Unknown Impurities
IUPAC Name:
Unknown Impurities
Test material form:
liquid
Specific details on test material used for the study:
Sample marking: 77-31, Baccartol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
No. of animals per sex per dose:
10 animals per dose (sex not reported)

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
0/10
Clinical signs:
No toxic signs
Gross pathology:
Necropsy Observations:
Lungs dark areas 6
Liver mottled 1
Kidney pale, mottled 5

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of Baccartol was found to be > 5000 mg/kg