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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Handbook and authoritative databases
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Determination of octanol water partition coefficient of the test substance 2-Hydroxy-4-methylbenzoic acid.
GLP compliance:
not specified
Type of method:
other: No data available
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Name of test material : 2-Hydroxy-4-methylbenzoic acid
- Molecular formula :C8H8O3
- Molecular weight :152.148 g/mol
- Smiles notation : Cc1ccc(c(c1)O)C(=O)O
- InChl :1S/C8H8O3/c1-5-2-3-6(8(10)11)7(9)4-5/h2-4,9H,1H3,(H,10,11)
- Substance Type: Organic
- Physical State: Solid
Key result
Type:
log Pow
Partition coefficient:
2.99
Remarks on result:
other: Other details not known
Details on results:
The logKow of test chemical 2-Hydroxy-4-methylbenzoic acid was determined to be 2.99.
Conclusions:
The partition coefficient (log Pow) value of the substance 2-Hydroxy-4-methylbenzoic acid was determined to be 2.99.
Executive summary:

The partition coefficient (log Pow) value of the substance 2-Hydroxy-4-methylbenzoic acid was estimated to be 2.99. Based on the estimated value, chemical 2-Hydroxy-4-methylbenzoic acid can be considered to be hydrophilic in nature.

Description of key information

Based on the available data from handbook and authoritative databases, the partition coefficient (log Pow) value of the substance 2-Hydroxy-4-methylbenzoic acid was estimated to be 2.99. Based on the estimated value, chemical 2-Hydroxy-4-methylbenzoic acid can be considered to be hydrophilic in nature.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.99

Additional information

Based on the available data in a key study from handbook and authoritative databases, octanol water partition coefficient (log Pow) value of the test substance 2-Hydroxy-4-methylbenzoic acid was estimated to be 2.99.

Additional supporting study from modelling databases indicates that the partition coefficient (log Pow) value of the substance 2-Hydroxy-4-methylbenzoic acid was estimated to be 2.79.

Thus, on the basis of logPow value, chemical 2-Hydroxy-4-methylbenzoic acid can be considered to be hydrophilic in nature.