Tetrasodium 2-(1,2-dicarboxylatoethylimino)succinate

Toxicity to reproduction

Administrative data

Endpoint:

one-generation reproductive toxicity

Type of information:

experimental study

Adequacy of study:

key study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Limit test:

no

Test material

Test material information

Constituent 1

Test animals

Species:

rat

Strain:

other:

Sex:

male/female

Administration / exposure

Route of administration:

oral: drinking water

Results and discussion

Results: P0 (first parental generation)

General toxicity (P0)

Clinical biochemistry findings:

not examined

Urinalysis findings:

not examined

Behaviour (functional findings):

not examined

Immunological findings:

not examined

Effect levels (P0)

1

Dose descriptor:

NOAEL

Effect level:

4 000 ppm

Based on:

test mat.

Sex:

male/female

Basis for effect level:

gross pathology

histopathology: non-neoplastic

2

Dose descriptor:

NOAEL

Effect level:

16 000 ppm

Based on:

test mat.

Sex:

male/female

Remarks on result:

other:

Target system / organ toxicity (P0)

Critical effects observed:

yes

Lowest effective dose / conc.:

16 000 ppm

System:

urinary

Organ:

bladder

kidney

Treatment related:

yes

Dose response relationship:

yes

Results: P1 (second parental generation)

Effect levels (P1)

Remarks on result:

other:

Results: F1 generation

Effect levels (F1)

Dose descriptor:

NOAEL

Generation:

F1

Effect level:

16 000 ppm

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other:

Results: F2 generation

Effect levels (F2)

Remarks on result:

other:

Overall reproductive toxicity

Reproductive effects observed:

no