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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
one-generation reproductive toxicity
Type of information:
experimental study
Adequacy of study:
key study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Limit test:
no

Test material

Test animals

Species:
rat
Strain:
other:
Sex:
male/female

Administration / exposure

Route of administration:
oral: drinking water

Results and discussion

Results: P0 (first parental generation)

General toxicity (P0)

Clinical biochemistry findings:
not examined
Urinalysis findings:
not examined
Behaviour (functional findings):
not examined
Immunological findings:
not examined

Effect levels (P0)

open allclose all
Dose descriptor:
NOAEL
Effect level:
4 000 ppm
Based on:
test mat.
Sex:
male/female
Basis for effect level:
gross pathology
histopathology: non-neoplastic
Dose descriptor:
NOAEL
Effect level:
16 000 ppm
Based on:
test mat.
Sex:
male/female
Remarks on result:
other:

Target system / organ toxicity (P0)

Critical effects observed:
yes
Lowest effective dose / conc.:
16 000 ppm
System:
urinary
Organ:
bladder
kidney
Treatment related:
yes
Dose response relationship:
yes

Results: P1 (second parental generation)

Effect levels (P1)

Remarks on result:
other:

Results: F1 generation

Effect levels (F1)

Dose descriptor:
NOAEL
Generation:
F1
Effect level:
16 000 ppm
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other:

Results: F2 generation

Effect levels (F2)

Remarks on result:
other:

Overall reproductive toxicity

Reproductive effects observed:
no

Applicant's summary and conclusion