Registration Dossier
Registration Dossier
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EC number: 500-744-0 | CAS number: 162492-10-6 1 - 6.5 moles propoxylated
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental toxicokinetic study is available on the registered substance. However, as per REACH guidance document R7. C (2014), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties. Based on these data, the registered substance could be well absorbed after oral or inhalation exposure. However a low absorption is expected after dermal exposure.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
No experimental toxicokinetic study is available on the registered substance. However, as per REACH guidance document R7. C (2014), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, including:
-Molecular weight (mean): 515.65 g/mol [443 -617]
-Water solubility: 51,4 g/L (20°C)
-Partition coefficient Log Kow > 6.2
-Vapour pressure: 9.53 x 10^-6
ABSORPTION
Oral absorption: The registered substance is water-soluble which readily dissolve into the gastrointestinal fluids. Absorption of very hydrophilic substances by passive diffusion may be limited by the rate at which the substance partitions out of the gastrointestinal fluid. The absorption of the registered substance is confirmed in the 28 -days repeated toxicity study in which systemic toxicity was observed in rats treated by gavage at the dose of 1000 mg/kg/day. The default value of oral absorption is considered to be 100%.
Dermal absorption: With a log Kow above 6, the rate of transfer between the stratum corneum and the epidermis will be slow and will limit absorption across skin. Uptake into the stratum corneum itself may be slow. Moreover, the acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Diethylamine modified ethoxylated trimethylolpropane triacrylate showed a strong allergic reaction in the LLNA. The dermal absorption is expected to be low. Based on the high molecular weight and the log kow outside the range [-1, 4], a default value of 10% of skin absorption is proposed.
Inhalation absorption: Based on the low value of the vapour pressure, the registered substance is considered to not be a volatile substance. However, based on the chemical data on the substance, absorption after inhalation exposure could be expected. The default value of inhalation absorption is considered to be 100%.
DISTRIBUTION and METABOLISM
The molecule is lipophilic (log Kow>0), it is likely to distribute into cells and the intracellular concentration may be higher than extracellular concentration particularly in fatty tissues.
No specific data is available on the metabolism of Diethylamine modified ethoxylated trimethylolpropane triacrylate.
ELIMINATION
Due to the good water solubility, the substance could be excreted by urine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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