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EC number: 238-947-9 | CAS number: 14874-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute oral LD50 of rhodium dicarbonyl acetylacetonate was determined to be in the range of 50-500 mg/kg bw (Middleton and Husband, 1978).
In a limit test, the acute dermal LD50 of acetylacetonatodicarbonyl rhodium (I) was found to exceed 2000 mg/kg bw (Collier, 1981).
No relevant acute inhalation toxicity data were identified.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study does not follow modern guideline, but data are reasonaly well documented and scientifically acceptable. Limited reporting of test material (e.g. purity).
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- A range finding study using groups of two rats (one male, one female) at five dose levels was conducted to identify the highest dose at which no deaths occurred. In the main study, a further group of 10 rats (5 male, 5 female) was treated at this dose.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Olac, Shaws Farm, Blackthorn, Bicester, Oxon
- Age at study initiation: “young adult”
- Weight at study initiation: 170-235 g
- Fasting period before study: overnight
- Housing: 5 rats (of one sex) in polypropylene cages
- Diet (e.g. ad libitum):ad libitum oxoid maintenance diet supplied by Herbert C. Styles (Bewdley) Ltd
- Water (e.g. ad libitum): ad libitum
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): “thermostatically controlled room”
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): “controlled lighting conditions”
IN-LIFE DATES: From: To: no data - Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Details on oral exposure:
- A single dose was administed orally by stomach tube using a rubber catheter. Test material was delivered in a total volume of 10 ml vegetable oil.
- Doses:
- Range finding study: 25, 50, 200, 500 and 2000 mg/kg bw.
Main study: 50 mg/kg bw. - No. of animals per sex per dose:
- Range finding study: one rat/sex/dose
Main study: five rats/sex/dose - Control animals:
- no
- Details on study design:
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- Duration of observation period following administration: 14 days- Frequency of observations and weighing: Animals were weighed immediately prior to dosing. The animals were examined immediately after dosing, four-hours after dosing, and then daily for 14 days for signs of toxicity.
- Necropsy of survivors performed: no
- Other examinations performed: none - Statistics:
- No statistical analysis was performed.
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 50 - < 500 mg/kg bw
- Mortality:
- In the range-finding study, both the male and the female rats died (24 hrs and 4 days after dosing, respectively) at 2000 mg/kg bw. The females in the 500 and 200 mg/kg bw dose level groups died (at 4 days and 3 days after dosing, respectively). No deaths were seen at the 50 mg/kg bw dose level or below. In the main study, one of the group of five females died at the selected treatment level of 50 mg/kg bw. The remaining females and all five treated males survived the 14 day observation period.
- Clinical signs:
- other: Not reported.]
- Gross pathology:
- Not reported.]
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral LD50 value of rhodium dicarbonyl acetylacetonate in rats was established to be within the range of 50-500 mg/kg bw.
- Executive summary:
The acute oral toxicity of rhodium dicarbonyl acetylacetonate was assessed in rats, using a method equivalent to OECD Test Guideline 401. In a range finding study, groups of Sprague-Dawley rats (1/sex/group) were administered the test item at doses of 25, 50, 200, 500 or 2000 mg/kg bw by stomach tube. Both rats died in the 500 and 2000 mg/kg bw dose groups, within four days of treatment. The female rat treated at 200 mg/kg bw died three days post-treatment. Therefore, in the main study, groups of five rats/sex were administered a dose of 50 mg/kg bw. One female rat died three days after treatment. The remaining animals survived the 14 day observation period and were reported to show “no overt signs of toxicity”.
The acute oral median lethal dose (LD50) of rhodium dicarbonyl acetylacetonate was determined to be between 50 and 500 mg/kg bw. Based on the results of this study, rhodium dicarbonyl acetylacetonate should be classified for acute oral toxicity (category 3) according to EU CLP criteria (EC 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 50 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 January 1981 – 10 February 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study apparently performed according to the method described by Noakes DN and Sanderson DM (1969) Br. J. ind. Med. Vol. 26, P. 59-64, which has some deviations from current OECD guidelines. Limited reporting, notably of test material (e.g. purity).
- Qualifier:
- according to guideline
- Guideline:
- other: Noakes DN and Sanderson DM (1969) Br. J. ind. Med. Vol. 26, P. 59-64
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- The animals were prepared by closely clipping the hair “on the day of the test” (guideline states that this should be done approx. 24 hrs before the test), the animals weighed between 210 and 400 g (guideline suggests rats weighing 200-300 g be used) and
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Tuck and Sons Ltd, Battlesbridge, Essex
- Weight at study initiation: 210-400 g
- Housing: individually during the exposure period and then in groups of up to 5 in solid floor polypropylene cages furnished with softwood sawdust
- Diet: ad libitum rat diet supplied by Nottingham University, Sutton Bonington, Near Loughborough, Leicestershire
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Air changes (per hr): a minimum of 20 air changes/hr
- Photoperiod (hrs dark / hrs light): lighting cycle of 12 hrs on and 12 hrs off with no daylight - Type of coverage:
- occlusive
- Vehicle:
- arachis oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: approx. 6 x 12 cm
- Type of wrap if used: elastic adhesive bandage backed with aluminium foil
REMOVAL OF TEST SUBSTANCE
- Washing (if done): skin and surrounding hair sponged thoroughly with detergent and warm water, rinsed and dried.
- Time after start of exposure: 24 hrs
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 g/kg bw
- Concentration (if solution): 200 mg/ml
- Constant volume or concentration used: yes
- For solids, paste formed: yes - suspension
VEHICLE
- Amount(s) applied (volume or weight with unit): 10 ml/kg bw - Duration of exposure:
- 24 hrs
- Doses:
- 2 g/kg bw
- No. of animals per sex per dose:
- 5 rats/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: ½, 1 and 4 hrs following treatment, and then once daily for 14 days
- Necropsy of survivors performed: yes, one male and one female
- Other examinations performed: clinical signs - Statistics:
- Acute dermal median lethal dose (LD50)
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: No deaths reported.
- Mortality:
- There were no mortalities throughout the 14 day observation period.
- Clinical signs:
- other: All animals showed subdued activity at the ½ hr observation period. No such effects were seen after 1 hr and no other clinical effects were noted.
- Gross pathology:
- No abnormal macroscopic lesions were seen in one male and one female survivor at termination of the study. (OECD guidelines recommend all animals are necropsied.)
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a limit test, the acute percutaneous median lethal dose (LD50) of acetylacetonatodicarbonyl rhodium (I) in the rat was found to be >2000 mg/kg bw.
- Executive summary:
Acetylacetonatodicarbonyl rhodium (I) was tested for its acute dermal toxicity in rats, using a method analogous to OECD Test Guideline 402 (with some minor deviations). A group of 5 male and 5 female Sprague-Dawley rats were treated dermally (application to clipped skin under occlusion; skin was clipped on the day of the test whereas the guideline recommends that this should be done approximately 24-hr before the test) with the test item at 2 g/kg bw (in arachis oil). After 24 hours the patch was removed, the skin washed and rinsed, and the rats observed for 14 days. No deaths or signs of overt toxicity were seen in either sex and there were no abnormal macroscopic lesions in the single necropsied male and female (OECD guidelines recommend all animals are necropsied).
Based on the results of this study, acetylacetonatodicarbonyl rhodium (I) should not be classified for acute dermal toxicity according to EU CLP criteria (EU 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
No relevant human acute toxicity data were identified.
The acute oral toxicity of rhodium dicarbonyl acetylacetonate was assessed in rats, using a method equivalent to OECD Test Guideline 401. In a range finding study, groups of Sprague-Dawley rats (1/sex/group) were administered the test item at doses of 25, 50, 200, 500 or 2000 mg/kg bw by stomach tube. Both rats died in the 500 and 2000 mg/kg bw dose groups, within four days of treatment. The female rat treated at 200 mg/kg bw died three days post-treatment. Therefore, in the main study, groups of five rats/sex were administered a dose of 50 mg/kg bw. One female rat died three days after treatment. The remaining animals survived the 14 day observation period and were reported to show “no overt signs of toxicity”. The acute oral median lethal dose (LD50) of rhodium dicarbonyl acetylacetonate was determined to be between 50 and 500 mg/kg bw (Middleton & Husband, 1978).
Acetylacetonatodicarbonyl rhodium (I) was tested for its acute dermal toxicity in rats, using a method analogous to OECD Test Guideline 402 (with some minor deviations). A group of 5 male and 5 female Sprague-Dawley rats were treated dermally (application to clipped skin under occlusion; skin was clipped on the day of the test whereas the guideline recommends that this should be done approximately 24-hr before the test) with the test item at 2 g/kg bw (in arachis oil). After 24 hours the patch was removed, the skin washed and rinsed, and the rats observed for 14 days. No deaths or signs of overt toxicity were seen in either sex and there were no abnormal macroscopic lesions in the single necropsied male and female (OECD guidelines recommend all animals are necropsied) (Collier, 1981).
No acute inhalation toxicity data were identified, or are required at this tonnage (1-10 tpa).
Justification for selection of acute toxicity – oral endpoint
OECD guideline equivalent study, and the only acute oral toxicity study available.
Justification for selection of acute toxicity – dermal endpoint
OECD guideline equivalent study (with some minor deviations), and the only acute dermal toxicity study available.
Justification for classification or non-classification
Based on the results of the available and reliable acute oral rat study, dicarbonyl(pentane-2,4-dionato-O,O')rhodium should be classified for acute oral toxicity (category 3) according to EU CLP criteria (EC 1272/2008).
No classification for acute dermal toxicity is required, based on the results of the available and reliable acute dermal rat study with dicarbonyl(pentane-2,4-dionato-O,O')rhodium.
No evidence of specific target organ toxicity was noted. As such, classification for STOT-SE is not considered appropriate.
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