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EC number: 914-468-7
CAS number: -
Effects on cholesterol biosynthesis:
50 mg/kg bw/day
*: significantly different from control
There were no alterations in body weight or organ weights (liver, heart,
kidneys, brain) due to exposure to the test substance.
Groups of Syrian hamsters (15 males per group) were fed diets delivering
body doses of 0, 25 or 50 mg/kg bw/day of very long chain fatty acids
(VLCFA, Licowax). Body weights and the weight of liver, heart, kidneys
and brain were unaffected by the treatment. Both treatments produced no
alterations in the levels of trigycerides. A slight, but not significant
increase of total cholesterol and non-HDL cholesterol was observed.
HDL-C was increased in both dosed groups, and this effect was
significant in the 50 mg/kg bw/day group. The ratio of TC to HDL-C was
not altered. The exposure to VLCFA increased the rate of biosynthesis of
cholesterol significantly at both doses, but there was no dose-response
relationship.Therefore the effects are not considered to be adverse, the
NOAEL of this study was >50 mg/kg/day.
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