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EC number: 222-377-2 | CAS number: 3453-33-6
Group/ Dose (mg/kg)
Body Weight (gram)
Body Weight Change (%)
Rats Body Weight (g)
Body Weight Changes (%)
Keys:SD = Standard Deviation, n = Number of Animals.
Hours (Day 0)
Days post dosing
Keys: 1 = Normal
Day of Observation (Day 0 to 14)
No mortality and morbidity
Mode of Death
No abnormality detected
Acute Oral Toxicity Study of Methyl 2-naphthyl ether in Rats was performed as per OECD No. 423.Six female Wistar rats were selected for acute oral toxicity study. The animals were fasted for minimum 16-18 hours prior to dosing and for 4 hours post dosing, with food withheld but drinking water providedad libitum. The time intervals between dosing were determined by the onset, duration and severity of toxic signs.
Three rats of group G1 were dosed with starting dose of 2000 mg/kg body weight and the animals showed no mortality post dosing, so another three rats of the same group were dosed with 2000 mg/kg weight and no mortality was observed. Hence, further dosing was stopped. Mean body weight of all six animals was observed with gain on day 7 and 14. Normal clinical signs were observed throughout the experimental period. No external and internal gross pathological examination were seen in all the six animals treated with 2000 mg/kg body weight during terminal sacrifice.Hence the LD50 value was considered to be >2000 mg/kg bw. From this value it is concluded that the substance Methyl 2-naphthyl etheris not classified as per CLP criteria.
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