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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 to 28 October 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
yes (incl. QA statement)
Remarks:
Staatliches Gewerbeaufsichtsamt Hildesheim
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
2.97
Temp.:
22.7 °C
Remarks on result:
other: No pH value was measured: mobile phase is neutral, the test item not influenced by pH.

Results

 

Preliminary test

A non-GLP preliminary test was performed, resulting in a log Pow of 2.94). The decision for the HPLC-method was made due to this result.

 

Results of the test item analysis

The table below contains the retention time data and calculated log k values for the test item. Two individual log Pow values were derived under consideration of the first and second calibration. Finally, a mean value was calculated from these individual log Pow values.

 

Retention Times, Capacity Factors and Partition Coefficients of the Test Item

[test item]

tR

[min]

k

log k

log Pow

1st Calibration

2nd Calibration

10.951

14.0

1.15

2.97 ± 0.05

2.83 to 3.11 (95% Cl)

2.97 ± 0.05

2.83 to 3.11 (95 % Cl)

10.956

14.0

1.15

Mean

10.954

14.0

1.15

2.97

tR: Retention time

k: Capacity factor test item

Pow: Partition Coefficient (n-octanol / water)

Cl: Confidence Interval

 

 

Final results

According to OECD Test Guidelines 117 (2004) and Council Regulation (EC) No. 440/2008 Method A.8, the partition coefficient (n-octanol / water) of the test item at 22.7 °C is log Pow = 2.97.

Conclusions:
A log Kow of 2.97 at 22.7 °C was determined for the test substance according to OECD 117.
Executive summary:

The partition coefficient (n-octanol / water) of test item was determined according to OECD Guideline 117 (2004) and GLP. The test was performed with a concentration of 200 mg/L test item in 60% methanol : 40% HPLC water via HPLC on a C18 column with diode array detection. The partition coefficient (n-octanol / water) log Pow was determined to be 2.97 at 22.7 °C.

Description of key information

Log Kow: 2.97 at 22.7 °C (OECD 117, HPLC method)

Key value for chemical safety assessment

Log Kow (Log Pow):
2.97
at the temperature of:
22.7 °C

Additional information

The partition coefficient (n-octanol / water) of test item was determined according to OECD Guideline 117 (2004) and GLP. The test was performed with a concentration of 200 mg/L test item in 60% methanol : 40% HPLC water via HPLC on a C18 column with diode array detection. The partition coefficient (n-octanol / water) log Pow was determined to be 2.97 at 22.7 °C.