Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-872-3 | CAS number: 498-94-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: AFNOR T03-263
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-piperidinecarboxylic acid
- EC Number:
- 207-872-3
- EC Name:
- 4-piperidinecarboxylic acid
- Cas Number:
- 498-94-2
- Molecular formula:
- C6H11NO2
- IUPAC Name:
- piperidine-4-carboxylic acid
- Test material form:
- solid
- Details on test material:
- lot n°003
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5-3.5 kg
- Housing: individual cages 65x50x60 cm
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 10 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 +1°C
- Humidity (%): 60 +/- 10%
- Air changes (per hr): 12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Remarks:
- two zones, one shaved, and one shaved and clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 24 hour
- Observation period:
- 1 hour, 24 hours and 72 hours after removal of the gauze
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2 cm2
- % coverage: 100%
- Type of wrap if used: sterile gauze
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
- Time after start of exposure: 24h
OBSERVATION TIME POINTS
1 hour, 24 hour, 72 hours
SCORING SYSTEM:
- Method of calculation: erythema score, edema score on shaved and clipped zone and on only shaved zone
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Score was 0 for all rabits, for all durations and all zones
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
