Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-333-2 | CAS number: 72089-08-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 to 12 August 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildeshelm
- Type of method:
- flask method
- Key result
- Water solubility:
- 28.2 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.6
- Conclusions:
- A water solubility value of 28.2 mg/L (at 20 °C, pH 6.6) was determined for the test substance according to OECD guideline 105.
- Executive summary:
The water solubility of the test item was determined according to OECD testing guideline 105 using flask method and GLP. The concentrations were measured via HPLC-DAD and the water solubility of test item was determined to be 28.2 mg/L at 20 °C.
Reference
Results
Preliminary Test (non GLP)
The determined solubility in double distilled water was in the range of 31.0 - 40.9 mg/L. For the application dose for the definitive study, approx. 0.409 g/L was used (approximately five times the maximum solubility result).
Main test
The results of the sampling are reported in the table below. No significant signals were obtained for the control sample.
Water Solubility Results at 20 °C
Preincubation time |
Replicate No. |
Concentration [1] (mg/L) |
Mean (mg/L) |
24 h |
1 |
26.63 [2] |
24.93 [2] |
2 |
23.23 [2] |
||
48 h |
1 |
26.5 |
27.7 |
2 |
28.8 |
||
72 h |
1 |
30.1 |
28.8 |
2 |
27.5 |
||
Mean (48 - 72 h) |
|
|
28.2 |
Deviation [%] (48 - 72 h) [3] |
|
|
4.1 |
[1] Mean value of two injections, dilution factor of 2 and exact weight of the standard taken into account
[2] Not taken into account; according to the guideline, a deviation < 15% for the samples with the two longest preincubation times (48 and 72 h) is sufficient
[3] Calculated according to the formula:
Deviation (%) = 100 x (max value - min value) / min value
SD Standard deviation
CV Coefficient of variation
Validity Criteria
The validity criteria were fulfilled:
- The concentration measured for the two longest incubation times did not differ by more than 15%.
- Temperatures were kept constant within ± 0.5 °C.
Conclusions
The solubility of the test item was determined at 20 ± 0.5 °C to be 28.2 mg/L (pH 6.6).
Description of key information
Water solubility: 28.2 mg/L at 20 °C, pH 6.6 (E.U. Method A.6, flask method)
Key value for chemical safety assessment
- Water solubility:
- 28.2 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined according to OECD-testing guideline 105 using flask method and GLP. The concentrations were measured via HPLC-DAD and the water solubility of test item was determined to be 28.2 mg/L at 20 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.