Registration Dossier
Registration Dossier
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EC number: 219-307-8 | CAS number: 2408-20-0
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
The hydrolysis half life at different pH and rate constant of test chemical 2-Propenyl Propanoate (CAS No. 2408-20-0) was estimated by EPI Suite (HydroWin). The Half life estimated at pH 7 was 274.146 days and at pH 8 was 27.415 days at temperature 25 oC. The rate Constant at pH > 8 was 0.2926 L/Mol/Sec at 25 oC. Since, half life of hydrolysis of chemical 2-Propenyl Propanoate is more than 10 days it shows negligible hydrolysis in water.
Additional information
Hydrolysis:
Predicted data for target compound 2-Propenyl Propanoate (CAS No.2408-20-0) and supporting weight of evidence studies for its read across chemicals were reviewed for the Hydrolysis endpoint which is summarized below.
In a prediction done to estimate the hydrolysis half life at different pH and rate constant of test chemical 2-Propenyl Propanoate (CAS No. 2408-20-0) by EPI Suite( Estimation Program Interface, 2017) HydroWin Program v.2.00. The estimated Half life at pH 7 was 274.146 days and at pH 8 was 27.415 days at temperature 25 oC. The rate Constant at pH > 8 was 0.2926 L/Mol/Sec at 25 oC. Since, half life of hydrolysis of chemical 2-Propenyl Propanoate is more than 10 days it shows negligible hydrolysis in water.
In a supporting weight of evidence study from authoritative database Hazardous Substance Data Bank ( HSDB, 2017) of read across chemical Ethyl Propanoate( CAS no. 105-37-3) the hydrolysis rate constant obtained was 0.089 L/mol/sec by base catalysed second order reaction. The half life of hydrolysis obtained at pH 7 was 2.5 years and at pH 8 was 90 days. Since half life of hydrolysis at both pH is more than 10 days so it is concluded that read across chemical Ethyl propanoate shows negligible hydrolysis.
In another supporting weight of evidence study from same source as mentioned above ( HSDB, 2017)of read across chemical Allyl acetate(CAS no. 591-87-7) the hydrolysis rate constant obtained was 0.194 L/mol/sec by alkaline second order reaction. The half life of hydrolysis obtained at pH 7 was 1.1 years and at pH 8 was 41 days. Since half life of hydrolysis at both pHs is more than 10 days so it is concluded that read across chemical Allyl acetate shows negligible hydrolysis.
On the basis of results for target chemical 2-Propenyl Propanoate (CAS No.2408-20-0) (From EPI Suite ) and for its read across chemicals (from HSDB, 2017) it is concluded that target chemical 2-Propenyl Propanoate is expected to show negligible hydrolysis.
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